Nutritional Advice El Mondo
Objectives:
Are there differences in coagulopathy indices in patients with severe and non-severe COVID-19?
Study design:
This review article included 35 retrospective studies with 6,427 COVID-19 patients.
16 studies were peer-reviewed and 19 were non-peer-reviewed.
Not surprisingly, quality assessment revealed a non-high study quality.
Across the studies, patients were predominantly male and approximately one-fourth of patients had a history of cardiovascular disease.
Results and conclusions:
The investigators found the primary analysis showed that mean D-dimer was significantly lower in COVID-19 patients with non-severe disease than in those with severe [SMD = -2.15, 95% CI = -2.73 to -1.56, I2 = 98%, p 0.0001].
Similarly, a lower mean D-dimer was found in survivors compared to non-survivors [SMD = -2.91, 95% CI = -3.87 to -1.96, I2 = 98%, p 0.0001].
The investigators found, additional analysis of platelet count showed higher levels of mean platelet count in non-severe patients than those observed in the severe group [SMD = 0.77, 95% CI = 0.32 to 1.22, I2 = 96%, p 0.001].
Similar result was observed when survivors were compared to non-survivors [SMD = 1.84, 95% CI = 1.16 to 2.53, I2 = 97%, p 0.0001].
The investigators found, shorter mean prothrombin time in both non-severe [SMD = -1.34, 95% CI = -2.06 to -0.62, I2 = 98%, p 0.0002] and survivors groups [SMD = -1.61, 95% CI = -2.69 to -0.54, I2 = 98%, p 0.003] compared to severe and non-survivor patients.
The investigators concluded that severe COVID-19 infection is associated with higher D-dimer values, lower platelet count and prolonged prothrombin time. These findings suggest a possible role of disseminated intravascular coagulation in the pathogenesis of COVID-19 disease complications.
Original title:
Differences in coagulopathy indices in patients with severe versus non-severe COVID-19: a meta-analysis of 35 studies and 6427 patients by Polimeni A, Leo I, […], Indolfi C.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8128869/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.