Nutritional Advice El MondoObjectives:
Parkinson's disease (PD) is among one of the common comorbidities in older patients. People with PD may be more vulnerable to severe pneumonia, due to the impairment of pulmonary function. Currently, the association between PD and COVID-19 is not yet established. Therefore, this review article has been conducted.
Does Parkinson's disease increase risk of severity and mortality from COVID-19?
Study design:
This review article included 12 studies with 103,874 COVID-19 patients.
Of 12 included studies, 9 studies were retrospective cohort, 1 study was prospective cohort, 1 study was case-control study, while the remaining 1 study was a cross-sectional study.
The funnel-plot analysis showed a qualitatively symmetrical inverted funnel-plot for the association between Parkinson's disease and in-hospital outcomes of COVID-19, indicating no publication bias.
Results and conclusions:
The investigators found pooled analysis showed that Parkinson's disease was significantly associated with poor in-hospital outcomes [OR = 2.64, 95% CI = 1.75 to 3.99, p 0.00001, I2 = 81%] and its subgroup which comprised of severe COVID-19 [OR = 2.61, 95% CI = 1.98 to 3.43, p 0.00001, I2 = 0%] and mortality from COVID-19 [RR = 2.63, 95% CI = 1.50 to 4.60, p = 0.0007, I2 = 91%].
Poor in-hospital outcomes did not changed in the sensitivity analysis [OR = 2.72, 95% CI = 2.21 to 3.35, p 0.00001, I2 = 6%].
The investigators found meta-regression showed that the association was influenced by age [p = 0.05], but not by gender [p = 0.46], hypertension [p = 0.44], diabetes [p = 0.58] and dementia [p = 0.23].
The investigators concluded Parkinson's disease is associated with an enhanced risk of severity and mortality from COVID-19. This association is influenced by age, but not by gender, hypertension, diabetes and dementia. Hence, patients with Parkinson's disease should be given extra care and monitoring to minimize exposure to the virus.
Original title:
Parkinson's disease may worsen outcomes from coronavirus disease 2019 (COVID-19) pneumonia in hospitalized patients: A systematic review, meta-analysis, and meta-regression by Putri C, Hariyanto TI, […], Kurniawan A.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8065236/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.