Nutritional Advice El MondoObjectives:
Does routine use of colchicine reduce COVID-19 severity and mortality?
Study design:
This review article included 8 studies with 5,778 COVID-19 patients.
Results and conclusions:
The investigators found meta-analysis showed that the administration of colchicine was significantly associated with improvement of outcomes of COVID-19 [OR = 0.43, 95% CI = 0.34 to 0.55, p 0.00001, I2 = 0%, fixed-effect modelling] and its subgroup which comprised of reduction from severe COVID-19 [OR = 0.44, 95% CI = 0.31 to 0.63, p 0.00001, I2 = 0%, fixed-effect modelling] and reduction of mortality rate from COVID-19 [OR = 0.43, 95% CI = 0.32 to 0.58, p 0.00001, I2 = 0%, fixed-effect modelling].
The investigators concluded that routine use of colchicine reduces COVID-19 severity and mortality. More randomized clinical trial studies are still needed to confirm these findings.
Original title:
Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID-19): A systematic review and meta-analysis by Hariyanto TI, Halim DA, […], Kurniawan A.
Link:
https://pubmed.ncbi.nlm.nih.gov/33719081/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.
Colchicine is a medication and it is used to prevent gout attacks (sudden, severe pain in one or more joints caused by abnormally high levels of a substance called uric acid in the blood) in adults.