Nutritional Advice El Mondo
Objectives:
Are comorbidities, like hypertension, diabetes, cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease and cancer associated with poor prognosis in COVID-19 patients?
Study design:
This review article included a total of 124 studies.
The mean age varied from a median of 40 to 84 years of age.
The NOS scores ranged between 5 and 8.
Results and conclusions:
The investigators found a higher risk for severity in COVID-19 patients with comorbidities.
The investigators found hypertension significantly increased risk of severity in COVID-19 patients with 157% [OR = 2.57, 95% CI = 2.12 to 3.11].
The investigators found diabetes significantly increased risk of severity in COVID-19 patients with 154% [OR = 2.54, 95% CI = 1.89 to 3.41].
The investigators found cardiovascular diseases significantly increased risk of severity in COVID-19 patients with 286% [OR = 3.86, 95% CI = 2.70 to 5.52].
The investigators found chronic obstructive pulmonary disease significantly increased risk of severity in COVID-19 patients with 171% [OR = 2.71, 95% CI = 1.98 to 3.70].
The investigators found chronic kidney disease significantly increased risk of severity in COVID-19 patients with 120% [OR = 2.20, 95% CI = 1.27 to 3.80].
The investigators found cancer significantly increased risk of severity in COVID-19 patients with 142% [OR = 2.42, 95% CI = 1.81 to 3.22].
The investigators found the risk for in‐hospital mortality was significantly increased in COVID‐19 patients with hypertension [OR = 2.50, 95% CI = 2.02 to 3.11], diabetes [OR = 2.09, 95% CI = 1.80 to 2.42], cardiovascular diseases [OR = 2.65, 95% CI = 1.87 to 3.77), chronic obstructive pulmonary disease [OR = 2.48, 95% CI = 2.05 to 3.00], chronic kidney disease [OR = 3.07, 95% CI = 2.43 to 3.88] or cancer [OR = 1.90, 95% CI = 1.57 to 2.30].
The investigators found, moreover, the prevalence of acute cardiac injury was higher in severe group than in nonsevere group and acute cardiac injury was associated with an increased risk for in-hospital mortality.
The investigators found univariable meta‐regression analyses showed there was a clearer effect of increasing age on the association between hypertension and diabetes and severity of COVID‐19. Conversely, there was no significant association between the proportion of males with the risk of severity or mortality.
The investigators concluded comorbidities, like hypertension, diabetes, cardiovascular diseases, chronic obstructive pulmonary disease, chronic kidney disease, cancer and acute cardiac injury are closely associated with poor prognosis in COVID-19 patients. It is necessary to continuously monitor related clinical indicators of organs injury and concern comorbidities in COVID-19 patients.
Original title:
The potential association between common comorbidities and severity and mortality of coronavirus disease 2019: A pooled analysis by Luo L, Fu M, […], Xu X.
Link:
https://onlinelibrary.wiley.com/doi/10.1002/clc.23465
Additional information of El Mondo:
Find more information/studies on coronavirus right here.