Nutritional Advice El Mondo
Objectives:
Many concerns still exist regarding the safety of hydroxychloroquine (HCQ) in the treatment of Coronavirus Disease 2019 (COVID-19). Therefore, this review article has been conducted.
What is the safety of hydroxychloroquine (HCQ) in the treatment of Coronavirus Disease 2019 (COVID-19)?
Study design:
This review article included 53 RCTs, involving 5,496 COVID-19 patients.
Results and conclusions:
The investigators found meta-analysis indicated that the risk of adverse effects (AEs) in the hydroxychloroquine (HCQ) group was significantly increased compared with that in the control group [RD = 0.05, 95% CI = 0.02 to 0.07, p = 0.0002] and the difference was also statistically significant in the COVID-19 subgroup [RD = 0.15, 95% CI = 0.07 to 0.23, p = 0.0002] as well as in the subgroup for other diseases [RD = 0.03, 95% CI = 0.01 to 0.04, p = 0.003].
The investigators concluded hydroxychloroquine (HCQ) is associated with a high total risk of adverse effects (AEs) compared with the placebo or no intervention in the overall population. Given the small number of COVID-19 participants included, it should be cautious regarding the conclusion stating that HCQ is linked with an increase incidence of AEs in patients with COVID-19. Therefore, well-designed and larger sample size studies are need in the future.
Original title:
Safety of hydroxychloroquine in COVID-19 and other diseases: a systematic review and meta-analysis of 53 randomized trials by Chen C, Pan K, […], Lv Q.
Link:
https://pubmed.ncbi.nlm.nih.gov/32780229/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.