Nutritional Advice El Mondo
Objectives:
Has oral supplementation of vitamin B (vitamins B1, B6, B12 and folic acid alone or combined) preventive effect on cognitive decline in cognitively unimpaired individuals?
Study design:
This review article included 20 RCTs, ranging from 23 to 2,919 participants per study, with a total of 12,697 participants.
8 of these 20 RCTs were deemed appropriate for the meta-analysis.
Results and conclusions:
The investigators found meta-analysis did not yield a significant overall effect of supplementation with vitamin B on cognitive function [SMD = 0.02, 95% CI = -0.034 to 0.08]. A sensitivity analysis focusing on specific risk factors did not alter this result.
Some studies reported isolated significant effects of the intervention on secondary outcomes. However, these findings were outnumbered by the number of cognitive tests that did not yield significant effects.
The investigators concluded there is no overall evidence that oral vitamin B supplementation prevent cognitive decline in cognitively unimpaired individuals. The results of this review do not provide evidence that population groups with certain risk factors would profit more from the intervention than others.
Original title:
Vitamin B-Can It Prevent Cognitive Decline? A Systematic Review and Meta-Analysis by Behrens A, Graessel E, [...], Donath C.
Link:
https://systematicreviewsjournal.biomedcentral.com/articles/10.1186/s13643-020-01378-7
Additional information of El Mondo:
Find more information/studies on vitamins B1, B6, B12 and folic acid and dementia right here.