Nutritional Advice El Mondo
Objectives:
The prevalence of co-infection of hepatitis B virus (HBV) and human immunodeficiency virus (HIV) is high and increases risk of hepatitis B chronicity and mortality. Despite guidelines for HIV-infected patients to be immunized against HBV, the immunogenicity of the HBV vaccination in HIV-infected patients is lower than that in the HIV-seronegative population. Therefore, this review article has been conducted.
What will be the response rate to an increased dose of HBV vaccination in HIV-infected patients?
Study design:
This review article included 9 RCTs, involving 970 HIV-positive vaccine recipients.
A fixed-effects model, with heterogeneity and sensitivity analyses, was used.
No heterogeneity was found.
Results and conclusions:
The investigators found results showed a significant increase in response rates among patients who received a double dose of the HBV vaccine versus the standard dose in both subgroups [pooled OR = 1.76, 95% CI = 1.36 to 2.29 and pooled OR = 2.28, 95% CI = 1.73 to 3.01] for the rate that was measured 4-6 weeks and >12 months after completion of vaccination, respectively.
The total OR was 1.99 [95% CI = 1.64 to 2.41].
The investigators concluded a double dose of the HBV vaccine improves the immune response in HIV-infected patients. Higher immunogenicity was observed, when it was measured 4-6 weeks and >12 months after completion of the vaccination.
Original title:
Systematic Review and Meta-Analysis of Immune Response of Double Dose of Hepatitis B Vaccination in HIV-infected Patients by Lee JH, Hong S, […], Kwon HY.
Link:
https://pubmed.ncbi.nlm.nih.gov/32334887/
Additional information of El Mondo:
Find more information/studies vaccination and malnutriton right here.