Nutritional Advice El Mondo
Objectives:
Is there an association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP) and fever?
Study design:
This review article included 18 studies with 3,278 patients, including 732 patients with poor outcomes.
Meta-regression analysis for leucocytosis (is a condition in which the white cell (leukocyte count) is above the normal range in the blood) indicated that age, dyspnea and hypertension contributed to heterogeneity.
Results and conclusions:
The investigators found fever, leucocytosis and elevated CRP were associated with poor outcomes [OR = 1.63, 95% CI = 1.06 to 2.51, OR = 4.51, 95% CI = 2.53 to 8.04 and OR = 11.97, 95% CI = 4.97 to 28.8], respectively.
Sensitivity analyses showed similar tendencies.
The investigators found, however, leukopenia (is a condition where a person has a reduced number of white blood cells) was associated with a better prognosis [OR = 0.56, 95% CI = 0.40 to 0.78].
Sensitivity analyses showed similar tendencies.
The investigators found the pooled area under the leukocytosis and CRP curves were 0.70 95% CI = 0.64 to 0.76] and 0.89, 95% CI = 0.80 to 0.99], respectively.
The investigators concluded in patients with COVID-19, fever, leukocytosis and an elevated CRP are associated with severe outcomes. Leukopenia is associated with a better prognosis. Moreover, leukocytosis and CRP on arrival could be biomarkers to predict severe COVID-19.
Original title:
Value of Leukocytosis and Elevated C-reactive Protein in Predicting Severe Coronavirus 2019 (COVID-19): A Systematic Review and Meta-Analysis by Yamada T, Wakabayashi M, […], Miyashita S.
Link:
https://www.sciencedirect.com/science/article/pii/S0009898120302709?via%3Dihub
Additional information of El Mondo:
Find more information/studies on coronavirus right here.