Nutritional Advice El Mondo
Objectives:
Has probiotic supplementation positive effects on the outcomes of preterm infants in India?
Study design:
This review article included 9 RCTs (n = 1,514).
Results and conclusions:
The investigators found in 9 RCTs that probiotics supplementation significantly reduced risk of necrotizing enterocolitis (NEC) ≥ Stage II with 64% [risk ratio = 0.36, 95% CI = 0.20 to 0.66, p = 0.0009].
The investigators found in 7 RCTs that probiotics supplementation significantly reduced risk of late onset sepsis with 44% [risk ratio = 0.56, 95% CI = 0.45 to 0.71, p 0.00001].
The investigators found in 8 RCTs that probiotics supplementation significantly reduced risk of mortality with 38% [risk ratio = 0.62, 95% CI = 0.41 to 0.95, p = 0.03].
The investigators found that probiotics supplementation significantly reduced the time to full feeds [mean difference = -4.09 d, 95% CI = -4.52 to -3.65, p 0.00001, 5 RCTs] and duration of hospital stay [MD = -2.00 d, 95% CI = -2.46 to -1.53, p 0.00001, 6 RCTs].
The investigators concluded probiotic supplementation has positive effects on the outcomes of preterm infants in India.
Original title:
Probiotics for Preterm Infants in India - Systematic Review and Meta-Analysis of Randomized Controlled Trials by Balasubramanian H, Ananthan A, […], Patole S.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/32185693
Additional information of El Mondo:
Find more information/studies on probiotic, pregnancy and food fortification right here.