Nutritional Advice El Mondo
Objectives:
Previous studies did not draw a consistent conclusion about the effects of vitamin K combined with vitamin D on human skeletal quality. Therefore, this review article has been conducted.
Does vitamin K combined with vitamin D supplementation increase bone mineral density (BMD)?
Study design:
This review article included 8 RCTs with a total of 971 participants.
Results and conclusions:
The investigators found vitamin K combined with vitamin D supplementation significantly increased total bone mineral density (BMD) [pooled effect size = 0.316, 95% CI = 0.031 to 0.601].
The investigators found vitamin K combined with vitamin D supplementation significantly decreased levels of undercarboxylated osteocalcin [effect size = -0.945, 95% CI = -1.113 to -0.778].
The investigators found simultaneously, subgroup analysis showed that K2 or vitamin K (not specified) supplement less than 500 μg/d, when combined with vitamin D significantly increased total bone mineral density compared with the control group fed a normal diet or the group with no treatment [effect size = 0.479, 95% CI = 0.101 to 0.858 and effect size = 0.570, 95% CI = 0.196 to 0.945, respectively).
The investigators concluded the combination of vitamin K and D supplement increases the total bone mineral density (BMD) and decreases levels of undercarboxylated osteocalcin and a more favorable effect is expected when less than 500 μg/d vitamin K2 is used.
Original title:
The combination effect of vitamin K and vitamin D on human bone quality: a meta-analysis of randomized controlled trials by Kuang X, Liu C, […], Li D.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/32219282
Additional information of El Mondo:
Find more information/studies on elderly, vitamin D and K right here.
Undercarboxylated osteocalcin represents inadequately carboxylated osteocalcin and this fraction increases with vitamin K insufficiency.