Nutritional Advice El MondoObjectives:
There are several guidelines that recommend pneumococcal vaccination (PPSV23 and/or PCV13) in adults with a history of cardiovascular disease (established heart failure, coronary disease, cerebrovascular disease) or at a very-high risk of cardiovascular disease. However, there is no Randomized Controlled Trial (RCT) systematic review that evaluates the impact of vaccination on all-cause mortality compared to no vaccination in this particular population. Therefore, this review article has been conducted.
Does pneumococcal vaccination decrease all-cause mortality in patients with cardiovascular disease or at a very high-cardiovascular risk?
Study design:
This review article included 5 observational studies enrolling a total of 163,756 participants.
Results and conclusions:
The investigators found pooled results from 5 studies enrolling a total of 163,756 participants showed a significant decrease of 22% for all-cause mortality [HR = 0.78, 95% CI = 0.73 to 0.83, I2 = 32%, very-low confidence].
The investigators concluded pneumococcal vaccination may decrease of all-cause mortality in patients with cardiovascular disease or at a very high-cardiovascular risk. However, limitations due to study design and the serious risk of bias in 3 of the included studies leads to a decreased level of result confidence.
Original title:
Pneumococcal vaccination in adults at very-high risk or established cardiovascular disease: systematic review and meta-analysis by Antunes MM, Duarte GS, […], Caldeira D.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/32259237
Additional information of El Mondo:
Find more information/studies on vaccination, food fortification and cardiovascular disease right here.