HPV vaccination during pregnancy does not increase adverse pregnancy outcomes

Objectives:
National immunization schedules in many countries recommend HPV vaccination for females until the age of 26 years and thus substantial numbers with reproductive age may be exposed to HPV vaccines. Therefore, this review article has been conducted.

Do inadvertent HPV vaccine exposures in the periconceptional period or during pregnancy increase risk of adverse pregnancy outcomes (spontaneous abortion, stillbirth, small for sestational age, preterm birth and birth defects)?

Study design:
This review article included 8 studies.

Results and conclusions:
The investigators found compared with the unexposed pregnancies, HPV vaccine exposed pregnancies were associated with no higher risk for:
-spontaneous abortion [RR = 0.99, 95% CI = 0.90 to 1.08];
-stillbirth (RR =1.16, 95% CI = 0.71 to 1.90];
-small for gestational age [RR = 0.96, 95% CI = 0.86 to 1.07];
-preterm birth [RR = 1.04 [95% CI = 0.91 to 1.18];
-birth defects [RR = 1.18, 95% CI = 0.97 to 1.43].

The investigators concluded inadvertent bivalent/quadrivalent HPV vaccination during pregnancy is not associated with significantly greater risks of adverse pregnancy outcomes.

Original title:
Pregnancy Outcomes After Human Papillomavirus Vaccination in Periconceptional Period or During Pregnancy: A Systematic Review and Meta-analysis by Wang A, Liu C, […], Huang Y.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/31486334

Additional information of El Mondo:
Find more information/studies on vaccination, pregnancy and food fortification/malnutrition right here.