Bivalent HPV vaccine offers protection against HPV16, HPV18 and HPV16/18 genotypes

Objectives:
The objective of this review article is to determine the effectiveness and harms of vaccination in patients with any sexual history to prevent the prevalence of papillomavirus infection.

Study design:
This review article included 29 studies described in 35 publications.

Results and conclusions:
The investigators found bivalent HPV vaccine offered protection against:
-HPV16 [RD = -0.05, 95% CI = -0.098 to -0.0032, I2 = 99%];
-HPV18 [RD = -0.03, 95% CI = -0.062 to -0.0004, I2 = 98%] and;
-HPV16/18 genotypes [RD = -0.1, 95% CI = -0.16 to -0.04, I2 = 99%].
It was consistent with 4 years for HPV16 and HPV18 genotypes.

The investigators found tetravalent HPV vaccine offered protection against:
-HPV6 [RD = -0.0500, 95% CI = -0.0963 to -0.0230, I2 = 66.8%];
-HPV11 [RD = -0.0198, 95% CI = -0.0310 to -0.0085, I2 = 0%].
-HPV16 [RD = -0.0608, 95% CI = -0.1126 to -0.0091, I2 = 76.4%] and;
-HPV18 [RD = -0.0200, 95% CI = -0.0408 to -0.0123, I2 = 34%].
It was consistent at 4 years for HPV6, HPV11, HPV16 and HPV18.

The investigators concluded there is a reduction in the prevalence of HPV16, 18 and 16/18 genotypes when applying the bivalent HPV vaccine, with no increase in adverse effects. Regarding the tetravalent HPV vaccine, there is a reduction in the prevalence of HPV6, 11, 16 and 18 genotypes, with no increase in adverse effects.

Original title:
The effectiveness of vaccination to prevent the papillomavirus infection: a systematic review and meta-analysis by García-Perdomo HA, Osorio JC, […], Castillo A.

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6518793/

Additional information of El Mondo:
Find more information/studies on food fortification/malnutrition and vaccination right here.

Papillomaviruses (HPVs) are double-stranded DNA viruses that affect epithelial cells. More than 100 strains of HPV have been detected. Approximately 40 strains are known to infect genital mucosa, of which about 15 strains are known to cause cancer. HPV types 16 and 18 are the most common cancer-causing strains, leading to about 70% of all cervical cancer cases worldwide. HPV types 6 and 11 are associated with about 90% of all cases of genital warts.