Nutritional Advice El MondoObjectives:
The emergence of vaccine-associated paralytic poliomyelitis has become an ongoing burden of poliomyelitis. Therefore, this review article has been conducted.
The objective of this review article is to compare the immunogenicity of sequential inactivated poliovirus vaccine (IPV) and oral poliovirus vaccines (OPV) versus inactivated poliovirus vaccine alone in healthy infants.
Study design:
This review article included 6 articles.
Results and conclusions:
The investigators found the results showed that seroconversion rates against all 3 serotype polioviruses were non-inferior and geometric mean antibody titers (GMTs) were superior in sequential schedules compared with IPV-only schedule. Thus, the sequential vaccination schedules could induce a stronger immunogenicity.
The investigators concluded to decrease vaccine-associated and vaccine-derived poliomyelitis, it is a reasonable option to select sequential schedules during this special transition from oral poliovirus vaccines to inactivated poliovirus vaccine-only immunization schedule, which coincides with the current WHO recommendations.
Original title:
Immunogenicity of sequential inactivated and oral poliovirus vaccines (OPV) versus inactivated poliovirus vaccine (IPV) alone in healthy infants: A systematic review and meta-analysis by Tang G, Yin W, […], Jiang X.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/29985751
Additional information of El Mondo:
Find more information/studies on food fortification/malnutrition and vaccination right here.