20 μg of HBV vaccine should be given for adults in China

Objectives:
Hepatitis B virus (HBV) infection remains an important public health problem in China and adults need to be vaccinated. Therefore, this review article has been conducted.

The aim of this review article is to assess the appropriate immunization of adults in China.

Study design:
This review article included 27 RCTs with a total of 18,308 participants.

The seroprotection was defined as anti-HBs≥ 10 mIU/mL.

Results and conclusions:
The investigators found 20 micrograms (20 μg) of HBV vaccine resulted in a better response than 10 micrograms [RR = 1.05, 95% CI = 1.02 to 1.08].  

The investigators found the 0-, 1- and 6-month schedule was more effective than the 0-, 1-, and 2 - or 3-month schedule [RR = 0.98, 95% CI = 0.96 to 1.00].

The investigators found no significant differences between:
-10 μg and 5 μg (yeast-derived hepatitis B vaccines) YDV [RR = 1.05, 95% CI = 0.88 to 1.01].
-10 μg and 5 μg recombinant Chinese hamster ovary cell (CHO) hepatitis B vaccine [RR = 1.01, 95% CI = 0.98 to 1.04].
-domestic and imported hepatitis B vaccines [RR = 1.02, 95% CI = 0.99 to 1.05].  
-0-, 1- and 6-month and 0-, 1- and 12-month schedules [RR = 1.02, 95% CI = 0.89 to 1.08].

The investigators concluded that 20 μg of HBV vaccine should be given for adults in China, and the 0-, 1- and 12-month immunization program schedule is also worth choosing when it is not possible to complete the 0-, 1- and 6-month schedule.

Original title:
Suitable hepatitis B vaccine for adult immunization in China: a systematic review and meta-analysis by Wu Z, Bao H, [...], Hu Y.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/30089437

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