Pneumococcal Conjugate Vaccine PCV10 and PCV13 reduce the hospitalization rates for pneumonia, particularly in children aged <24months

Objectives:
What is the impact of Pneumococcal Conjugate Vaccine with 10 pneumococcal serotypes PCV10 and PCV13 in reducing the incidence of Community-Acquired Pneumonia (CAP) hospitalizations in children aged 5years?

Study design:
This review article included 12 articles.

High heterogeneity was detected among studies evaluating the hospitalization rate for clinically and radiologically confirmed pneumonia.

Results and conclusions:
The investigators found in children aged 24 months a significantly reduction of 17% [95% CI = 11-22%, p 0.001] in the hospitalization rates for clinically confirmed pneumonia after the introduction of the novel PCVs.

The investigators found in children aged 24 months, a significantly reduction of 31% [95% CI = 26-35%, p 0.001] in the hospitalization rates for radiologically confirmed pneumonia after the introduction of the novel PCVs

The investigators found in children aged 24-59 months a significantly reduction of 9% [95% CI = 5-14%, p 0.001] in the hospitalization rates for clinically confirmed pneumonia after the introduction of the novel PCVs.

The investigators found in children aged 24-59 months, a significantly reduction of 24% [95% CI = 12-33%, p 0.001] in the hospitalization rates for radiologically confirmed pneumonia after the introduction of the novel PCVs

The investigators concluded there is a significant impact of PCV10 and PCV13 in reducing the hospitalizations for pneumonia, particularly in children aged 24months and for radiologically confirmed disease. Further appropriately designed studies, comparing the impact of PCV10 and PCV13, are needed in order to obtain solid data on which to establish future immunization strategies.

Original title:
The impact of 10-valent and 13-valent pneumococcal conjugate vaccines on hospitalization for pneumonia in children: A systematic review and meta-analysis by Alicino C, Paganino C, […], Ansaldi F.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/28911902

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