Nutritional Advice El MondoObjectives:
The results of randomized controlled trials (RCTs) investigating resveratrol supplementation on risk factors of non-communicable diseases (NCDs) have been inconsistent. Therefore, this review article (meta-analysis) has been conducted.
Does resveratrol supplementation reduce risk of non-communicable diseases?
Study design:
This review article included 29 RCTs (30 treatment arms) with 1069 participants.
Results and conclusions:
The investigators found that resveratrol supplementation significantly reduced the concentrations of:
-fasting glucose [-4.77 mg/dL, 95% CI = -9.33 to -0.21 mg/dL, p = 0.040];
-total cholesterol (TC) [-9.75 mg/dL, 95% CI = -17.04 to -2.46 mg/dL, p = 0.009] and;
-C-reactive protein (CRP) [-0.81 mg/L, 95% CI = -1.42 to -0.21 mg/L, p = 0.009].
The investigators found that resveratrol intervention exerted significant reductions in systolic blood pressure (SBP) and diastolic blood pressure (DBP) in subjects with type 2 diabetes mellitus (T2DM).
The investigators found subgroup analysis also showed that the trials with resveratrol intervention ≥3 months significantly reduced the low-density lipoprotein (LDL) cholesterol (bad cholesterol), diastolic blood pressure and glycated hemoglobin (HbA1c) values.
The investigators found that resveratrol intervention had no favourable effects in altering high-density lipoprotein (HDL) cholesterol (good cholesterol), triglyceride (TAG) and homeostasis model assessment of insulin resistance (HOMA-IR).
The investigators concluded resveratrol supplementation ≥3 months has favourable effects on several risk factors of non-communicable diseases.
Original title:
Effects of resveratrol supplementation on risk factors of non-communicable diseases: A meta-analysis of randomized controlled trials by Guo XF, Li JM, [...], Li D.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/28933578
Additional information of El Mondo:
Find more information/studies on flavonoids, cholesterol, blood pressure, diabetes and chronic diseases right here.
Non-communicable or chronic diseases are diseases of long duration and generally slow progression. The four main types of non-communicable diseases are cardiovascular diseases (like heart attacks and stroke), cancer, chronic respiratory diseases (such as chronic obstructed pulmonary disease and asthma) and diabetes.
Non-communicable diseases are by far the leading cause of death in the world.