Nutritional Advice El Mondo
Objectives:
Do rotavirus vaccines reduce risk of rotavirus gastroenteritis (RVGE) in children younger than 5 years?
Study design:
This review article included 20 RCTs and 38 case-control studies.
Results and conclusions:
The investigators found a meta-analysis of 20 RCTs and 38 case-control studies revealed that Rotarix (RV1) vaccines significantly reduced rotavirus gastroenteritis risk with 68.4% [RR = 0.316, 95% CI = 0.224 to 0.345] and rotavirus gastroenteritis hospitalization risk with 65.3% [OR = 0.347, 95% CI = 0.279 to 0.432] among children fully vaccinated.
The investigators found a meta-analysis of 20 RCTs and 38 case-control studies revealed that RotaTeq (RV5) vaccines significantly reduced rotavirus gastroenteritis risk with 65% [RR = 0.35, 95% CI = 0.275 to 0.445] and rotavirus gastroenteritis hospitalization risk with 72.8% [OR = 0.272, 95% CI = 0.197 to 0.376] among children fully vaccinated.
The investigators found rotavirus vaccines also demonstrated higher protection against severe rotavirus gastroenteritis.
The investigators found no significant differences in the protection of RV1 and RV5 against rotavirus disease were noted in adjusted indirect comparisons.
The investigators found moderate associations were seen between reduced rotavirus gastroenteritis risk and Rotavac [RR = 0.664, 95% CI = 0.548 to 0.804], Rotasiil [RR = 0.705, 95% CI = 0.605 to 0.821] and Lanzhou lamb rotavirus vaccine [RR = 0.407, 95% CI = 0.332 to 0.499].
The investigators found all rotavirus vaccines demonstrated no risk of serious adverse events.
The investigators found a positive correlation was also seen between immunogenicity and vaccine protection [e.g., association of rotavirus gastroenteritis with RV1: coefficient = -1.599, adjusted R2 = 99.7%].
The investigators concluded that the high protection and low risk of serious adverse events for rotavirus vaccines in children who were fully vaccinated emphasize the importance of worldwide introduction of rotavirus vaccination in children younger than 5 years. Similar protection provided by Rotarix and RotaTeq relieves the pressure of vaccines selection for health care authorities.
Original title:
Association of Rotavirus Vaccines With Reduction in Rotavirus Gastroenteritis in Children Younger Than 5 Years: A Systematic Review and Meta-analysis of Randomized Clinical Trials and Observational Studies by Sun ZW, Fu Y, […], Xu HG.
Link:
https://pubmed.ncbi.nlm.nih.gov/33970192/
Additional information of El Mondo:
Find more information/studies on RCTs/cohort/significantly/review article, vaccination and food fortification/malnutrition right here.
Rotavirus gastroenteritis is the most common cause of severe diarrhoea in children under the age of 5. Rotavirus gastroenteritis is caused by rotavirus. It’s highly contagious and easily transmittable.