Nutritional Advice El Mondo
Objectives:
Since licensure in 2006, rotavirus vaccines have been introduced in more than 100 countries. However, the efficacy of rotavirus vaccines is variable in settings with different child mortality levels. Therefore, this review article has been conducted.
What is the efficacy of rotavirus vaccines in settings with different child mortality levels?
Study design:
This review article included 60 studies from 32 countries. 31 studies were from countries with low child mortality, 8 were from medium-mortality countries and 21 were from high-mortality countries.
There was no substantial heterogeneity [I2 range: 0-36%].
Results and conclusions:
The investigators found rotarix vaccine effectiveness against laboratory-confirmed rotavirus among children younger than 12 months old was 86% [95% CI = 81% to 90%] in low-mortality countries, 77% [95% CI = 66% to 85%] in medium-mortality countries and 63% [95% CI = 54% to 70%] in high-mortality countries.
The investigators found rotarix vaccine effectiveness among children aged 12-23 months was 86% [95% CI = 81% to 90%] in low-mortality countries, 54% [95% CI = 23% to 73%] in medium-mortality countries and 58% [95% CI = 38% to 72%] in high-mortality countries.
The investigators found rotateq vaccine effectiveness among children younger than 12 months was 86% [95% CI = 76% to 92%] in low-mortality countries and 66% [95% CI = 51% to 76%] in high-mortality countries.
The investigators found rotateq vaccine effectiveness among children aged 12-23 months was 84% [95% CI = 79% to 89%] in low-mortality countries.
The investigators found median vaccine effectiveness in low-mortality countries was similar for rotarix [83%, IQR = 78% to 91%], rotateq [85%, IQR = 81% to 92%], mixed series [86%, IQR = 70% to 91%] and non-product-specific [89%, IQR = 75% to 91%] vaccination.
The investigators concluded rotavirus vaccines are effective in preventing rotavirus diarrhoea, with higher performance in countries with lower child mortality.
Original title:
Real-world effectiveness of rotavirus vaccines, 2006-19: a literature review and meta-analysis by Burnett E, Parashar UD and Tate JE.
Link:
https://pubmed.ncbi.nlm.nih.gov/32827481/
Additional information of El Mondo:
Find more information/studies on vaccination and malnutrition right here.