Nutritional Advice El Mondo
Objectives:
Despite the universal use of the two-dose trivalent measles-mumps-rubella (MMR) vaccine in the past two decades, outbreaks of these diseases still occur in countries with high vaccine uptake, giving rise to concerns about primary and secondary failure of MMR vaccine components. Therefore, this review article has been conducted.
What is the seroconversion and waning rate estimates for the measles, mumps and rubella components of MMR vaccines?
Study design:
This review article included 62 studies.
Results and conclusions:
The investigators found estimated overall seroconversion rates were 96.0% [95% CI = 94.5 to 97.4, I2 = 91.1%] for measles, 93.3% [95% CI = 91.1 to 95.2, I2 = 94.9%] for mumps when excluding the Rubini strain, 91.1% [95% CI = 87.4 to 94.1, I2 = 96.6%] for mumps when including the Rubini strain and 98.3% [95% CI = 97.3 to 99.2, I2 = 93.0%] for rubella.
The investigators found estimated overall annual waning rates were 0.009 [95% CI = 0.005 to 0.016, I2 = 85.2%] for measles, 0.024 [95% CI = 0.016 to 0.039, I2 = 94.7%] for mumps, and 0.012 [95% CI = 0.010 to 0.014, I2 = 93.3%] for rubella.
The investigators concluded this meta-analysis provides estimates of primary and secondary vaccine failure, which are essential to improve the accuracy of mathematical and statistical modelling to understand and predict the occurrence of future measles, mumps and rubella outbreaks in countries with high vaccine uptake.
Original title:
Immunogenicity and persistence of trivalent measles, mumps, and rubella vaccines: a systematic review and meta-analysis by Schenk J, Abrams S, [...], Hens N.
Link:
https://pubmed.ncbi.nlm.nih.gov/32888410/
Additional information of El Mondo:
Find more information/studies on measles and malnutrition right here.