Nutritional Advice El Mondo
Objectives:
Are there differences in serum ceruloplasmin levels between patients with preeclampsia and healthy controls?
Study design:
This review article included 15 studies, with a total number of 1927 women.
Results and conclusions:
The investigators found that maternal serum ceruloplasmin concentration was significantly higher in preeclamptic than in the healthy pregnant women [MD = 12.57 mg/dL, 95% CI = 8.81 to 16.33].
The investigators found that ceruloplasmin levels were significantly higher both in mild [MD = 13.8 mg/dL, 95% CI = 2.64 to 23.53] and severe [MD = 21.84 mg/dL, 95% CI = 0.97 to 42.71] preeclampsia, when compared to the control group.
The investigators found that the severity of the disease did not significantly affect the levels of protein [MD = -9.34 mg/dL, 95% CI = -20.93 to 2.26].
The investigators concluded that serum ceruloplasmin may be a useful screening and follow-up tool for the evaluation of pregnant women with an indicative history of developing preeclampsia. Future studies are needed to evaluate the levels of this specific protein throughout the pregnancy course and provide data on its sensitivity and specificity by introducing cut-off values.
Original title:
Serum ceruloplasmin levels in preeclampsia: a meta-analysis by Bellos I, Papantoniou N and Pergialiotis V.
Link:
https://www.ncbi.nlm.nih.gov/pubmed/28605950
Additional information of El Mondo:
Find more information/studies on copper, pregnancy and review article/significant/95% CI right here.
Ceruloplasmin carries 65% to 90% of the copper found in blood.