Severe COVID-19 patients have a 4.74-fold increase in risk of myocardial injury

Objectives:
Coronavirus disease 2019 (COVID-19) has become global pandemic and resulted in considerable morbidity and mortality since December 2019. Information on the incidence of myocardial injury remains scarce. Therefore, this review article has been conducted.

Does myocardial injury increase severe COVID-19 infection?

Study design:
This review article included 53 studies, involving 7,679 COVID-19 patients.

Results and conclusions:   
The investigators found pooled incidence of myocardial injury was 21% [95% CI = 17% to 25%, I2 = 96.5%].

The investigators found the highest incidence of myocardial injury was found in non-survivors [66%, 95% CI = 54% to 78%, I2 = 85.7%], followed by severe patients [43%, 95% CI = 33% to 53%, I2 = 93.0%] and non-severe patients [11%, 95% CI = 7% to 15%, I2 = 95.2%].

The investigators found higher risk of myocardial injury was detected in severe patients than non-severe patients [RR = 5.74, 95% CI = 3.74 to 8.79, I2 = 86.8%].

The investigators found sensitivity analyses confirmed the robustness of primacy results.

The investigators concluded that myocardial injury occurs in 21% of COVID-19 patients. An elevated rate is observed in non-survivors (66%) and severe patients (43%). Severe COVID-19 patients have a 4.74-fold increase in the risk of myocardial injury than non-severe patients. Aggressive strategy may be considered for COVID-19 patients at high risk of myocardial injury.

Original title:
Incidence of myocardial injury in coronavirus disease 2019 (COVID-19): a pooled analysis of 7,679 patients from 53 studies by Gu ZC, Zhang C, [...], Pu J.

Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7487385/

Additional information of El Mondo:
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