Nutritional Advice El Mondo
Objectives:
Is there an association between all-cause mortality of COVID-19 and age?
Study design:
This review article included all available national reports on May 7, 2020 from China, Italy, Spain, United Kingdom and New York State with a total of 611,1583 COVID-19-positive patients, of which 141,745 (23.2%) were aged ≥80 years.
The percentage of octogenarians (persons whose age are in the eighties) was different in the 5 registries, the lowest being in China (3.2%) and the highest in the United Kingdom and New York State.
Meta-regression identified sample size [p = 0.002], countries [p = 0.001] and mean age [p = 0.001] as significant sources of heterogeneity; the small-effect study was also observed [Harbor test, p = 0.013].
Results and conclusions:
The investigators found the overall mortality rate was 12.10% and it varied widely between countries, the lowest being in China (3.1%) and the highest in the United Kingdom (20.8%) and New York State (20.99%).
The investigators found mortality was 1.1% in patients aged 50 years and it increased exponentially after that age in the 5 national registries.
The investigators found, as expected, the highest mortality rate was observed in patients aged ≥80 years.
The investigators found all age groups had significantly higher mortality compared with the immediately younger age group.
The investigators found the largest increase in mortality risk was observed in patients aged 60 to 69 years compared with those aged 50 to 59 years [odds ratio = 3.13, 95% CI = 2.61 to 3.76].
The investigators found patients aged >80 years had 60% higher risk of dead compared to patients with age 70 to79 years but it was 6-fold higher [odds ratio = 6.25, 95% CI = 5.38 to 7.25, p 0.001] if they were compared to all patients aged 80 years.
The investigators concluded this meta-analysis with more than half million of COVID-19 patients from different countries highlights the determinant effect of age on mortality with the relevant thresholds on age >50 years and especially, >60 years. Older adult patients should be prioritized in the implementation of preventive measures.
Original title:
The Effect of Age on Mortality in Patients With COVID-19: A Meta-Analysis With 611,583 Subjects by Bonanad C, García-Blas S, […], Cordero A.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7247470/
Additional information of El Mondo:
Find more information/studies on coronavirus right here.