Nutritional Advice El Mondo
Objectives:
Does niacin (vitamin B3) supplementation improve lipid profiles and glycemic control in patients with type 2 diabetes mellitus?
Study design:
This review article included 8 RCTs comprised a total of 2,110 patients with type 2 diabetes mellitus.
Studies published ranged from 1990 to 2016 and 15 to 1,053 patients were included in each individual trial.
The follow-up duration ranged from 8.0 weeks to 12.0 months.
The study quality was assessed using the Jadad scale. 4 studies had 3 scores and the remaining 4 studies had 2 scores.
There was no significant publication bias.
Results and conclusions:
The investigators found patients’ niacin supplementation was associated with lower levels of total cholesterol [WMD = -0.28, 95% CI = -0.44 to -0.12, p = 0.001], triglyceride [WMD = -0.37, 95% CI = -0.52 to -0.21, p 0 .001] and low-density lipoprotein cholesterol (bad cholesterol) [WMD = -0.42, 95% CI = -0.50 to -0.34, p 0.001].
The investigators found, moreover, the level of high-density lipoprotein cholesterol (good cholesterol) was significantly increased when niacin supplementation [WMD = 0.33, 95% CI = 0.21 to 0.44, p 0 .001] was provided.
The investigators found, however, niacin supplementation produced no significant effects on plasma glucose [WMD = 0.18, 95% CI = -0.14 to 0.50, p = 0 .275] and hemoglobin A1c (HbA1c) levels [WMD = 0.39, 95% CI = -0.15 to 0.94, p = 0 .158].
The investigators concluded that niacin (vitamin B3) supplementation improves lipid profiles, including total cholesterol, LDL and HDL cholesterol without affecting the glycemic levels for patients with type 2 diabetes mellitus. Additional large-scale RCTs should be conducted to evaluate the long-term effectiveness of niacin supplementation.
Original title:
Effectiveness of niacin supplementation for patients with type 2 diabetes: A meta-analysis of randomized controlled trials by Xiang D, Zhang Q and Wang YT.
Link:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7373507/
Additional information of El Mondo:
Find more information/studies on cholesterol, vitamin B3 and diabetes right here.