Vitamin K supplementation has no effect on glycemic control

Objectives:
Type 2 diabetes mellitus (T2DM) is one of the most important public health issues. Vitamin K supplementation might have favorable effect on risk factors of T2DM. Therefore, this review article (meta-analysis) has been conducted.

Have vitamin K supplementation favorable effects on risk factors of type 2 diabetes mellitus?

Study design:
This review article included 5 RCTs with in total of 533 participants.

There was no evidence of publication bias.

Results and conclusions:
The investigators found overall, meta-analysis did not show any beneficial effect of vitamin K supplementation on both:
-fasting blood sugar levels [-0.91 mg/dL, 95% CI = -2.57 to 0.76, p = 0.28];
-fasting insulin levels [-0.35 μIU/mL, 95% CI = -1.70 to 1.00, p = 0.61];
-HOMA-IR [-0.06, 95% CI = -0.32 to -0.19, p = 0.63] and
-2-h oral glucose tolerance test [-4.00 mg/dL, 95% CI = -20.00 to 11.99, p = 0.62].

The investigators found sensitivity analysis showed that overall estimates were not affected by elimination of any study.

The investigators concluded that vitamin K supplementation has no significant effect on glycemic control in healthy subjects. However, further studies should be performed on diabetic and pre-diabetic patients to determine the effect of vitamin K supplementation on impaired glycemic control.

Original title:
Effect of Vitamin K Supplementation on Glycemic Control: A Systematic Review and Meta-Analysis of Clinical Trials by Shahdadian F, Mohammadi H and Rouhani M.

Link:
https://www.ncbi.nlm.nih.gov/pubmed/29523009

Additional information of El Mondo:
Find more information/studies on diabetes and vitamin K right here.