Voeding en gezondheid

Het eten van tomatenproducten verlaagt mogelijk maagkanker

Research Question:
Epidemiological studies have the possible association between the consumption of tomato products and stomach cancer examined, but the relationship between eating tomato products and the risk of getting stomach cancer is controversial. It was therefore carried out this review article.

Eating tomatoes lowers the chances of getting stomach cancer?

Study Design:
This overview article contained 21 studies. The studies were case-control or cohort studies.

Results and conclusions:
The researchers found in a pooled analysis of 21 studies that eating lots of tomatoes, the tomato products products compared with little chance of getting stomach cancer significantly with 27% reduced [odds ratio = 0.73, 95% CI = 0.60-0.90]. Significant is, there is a link at a 95% reliability.

The pooled odds ratio of the consumption of lycopene was 0.88 [95% CI = 0.67-1.16] and the pooled odds ratio of serum lycopene was 0.79 [95% CI = 0.59-1.07].

The researchers concluded that eating lots of tomato products the chance of getting stomach cancer may be reduced. Possible because there are errors in the studies were found, which could affect the results found.

Original title:
The role of tomato products and lycopene in the prevention of gastric cancer: A meta-analysis of an epidemiological studies by Yang T, Yang X, [...], Song Z.

Link:
http://www.medical-hypotheses.com/article/S0306-9877%2813%2900011-X/abstract

Additional information about El Mondo:
Risk factors of stomach cancer are:

  • Smoking
  • Certain type of stomach polyps
  • Stomach Removal
  • Chronic atrophic gastritis
  • Helicobacter pylori

 

25 mg lycopeen per dag verlaagt het LDL-cholesterolgehalte met 10%

Research Question:
Lowers eating lycopene cholesterol levels and blood pressure?

Study Design:
This overview article contained 12 Rcts.

Results and conclusions:
The researchers found that eating lycopene 25 mg or more per day total cholesterol significantly with 7.55 mg/dl [± 6.15 mg/dl, p = 0.02] reduced. Significant is, there is a link at a 95% reliability.

The researchers found that eating lycopene 25 mg or more per day the LDL-cholesterol levels significantly with 10.35 mg/dl [± 5.64 mg/dl, p = 0.0003] reduced. Significant is, there is a link at a 95% reliability.

The effect of lycopene on the total cholesterol and LDL-cholesterol levels lost its significance at an intake of less than 25 mg of lycopene per day. No significance is, there is no link to a 95% reliability.

The researchers found that eating lycopene 25 mg or more per day the systolic blood pressure significantly with 5.60 mmHg [± 5.26 mmHg, p = 0.04] reduced. Significant is, there is a link at a 95% reliability.

The researchers concluded that a lycopeeninname of 25 mg or more per day lowered LDL cholesterol by about 10%, which is comparable to the effect of a low dose statins in patients with a slightly raised cholesterol levels. More research is needed to further the suggested favourable effect on the total serum cholesterol levels and systolic blood pressure (bovenddruk) to confirm.

Original title:
Protective effect of lycopene on serum cholesterol and blood pressure: Meta-analyses or intervention trials by Ried Fakler K and P.

Link:
http://www.maturitas.org/article/S0378-5122%2810%2900446-9/abstract

Additional information about El Mondo:
Lycopene is a carotenoid and is responsible for the red color of the tomatoes.

 

Lycopeen verlaagt een beroerte onder mannen

Research Question:
Epidemiological studies support a protective role of lycopene against preventing a stroke or mortality, but the results are contradictory. It was therefore carried out this review article.

Eating lycopene reduces the chance of getting a stroke? 

Study Design:
This overview article contained 7 prospective cohort studies with 116127 participants and 1989 people with stroke.
There was no question of publication bias.

Results and conclusions:
The researchers found that lycopene the chance of getting a stroke significantly with 19.3% [RR = 0.807, 95% CI = 0680-0.957, I2 = 25.5%, p = 0.234] reduced.

The researchers found that lycopene lycopene in the blood and not through feeding, the chances of getting a stroke significantly with 38.7% [RR = 0.503-0693, 95% CI = 0.954] reduced.

The researchers found that lycopene the chance of stroke among Europeans and men lowered.

The researchers found that the duration of the follow-up had no effect on the final results.

The researchers concluded that lycopene, particularly in blood and not through feeding, the chance of getting a stroke, especially among Europeans and men lowered.

Original title:
Dietary and circulating lycopene and stroke risk: a meta-analysis of prospective studies by Li X and Xu J.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24848940

Additional information about El Mondo:
The lycopeengehalte in the blood can be increased by swallowing lycopeensupplementen and/or eating lycopene.

Find here more studies on lowering stroke and lycopene.

 

Lycopeensupplementen verlagen niet prostaatkanker

Research Question:
Lycopeensupplementen swallowing lowers the chances of getting prostate cancer?

Study Design:
This overview article contained 8 Rcts. There was talk of bias.

Results and conclusions:
The researchers found in a meta-analysis of 4 Rcts that swallowing lycopeensupplementen the chance of getting benign prostatic hyperplasia (a benign enlargement of the prostate) not significant with 5% [95% CI = 0.63-1.44] reduced.
Not significant is, there is no link to a 95% reliability.

The researchers found in a meta-analysis of 4 Rcts that swallowing lycopeensupplementen the chance of getting prostate cancer by 8% not significant [RR = 0.92, 95% CI = 0.66-1.29] reduced.
Not significant is, there is no link to a 95% reliability.

The researchers found in a meta-analysis of 2 Rcts that swallowing of lycopeensupplementen the value of PSA-prostate cancer patients significantly with 1.58 [95% CI =-2.61 to-0.55] reduced.
Significant is, there is a link at a 95% reliability.

The researchers concluded that it is not yet scientifically proven was to lycopeensupplementen for write for prevention or treatment of prostate cancer.

Original title:
Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: A systematic review by Ilic D and Valerie M.

Link:
http://www.maturitas.org/article/S0378-5122%2812%2900160-0/abstract

Additional information about El Mondo:
Read more about lycopeenstudies.

Prostate cancer is rare in men younger than 40 years.

The Prostate specific antigen (PSA) is a protein that is normally present in the blood to a small degree. It is formed in the glandular tissue of the prostate, both in a healthy as in a diseased prostate.
In benign prostatic hyperplasia (BPH) and prostate cancer, the PSA level increased.

Age (years)

Reference value of PSA

40-49

2.5

50-59

3.5

60-69

4.5

70-79

6.5

 

 

Beta-cryptoxanthine via voeding verlaagt longkanker

Research Question:
The eating of carotenoids reduces chances of getting lung cancer?

Study Design:
This overview article contained 7 cohort studies with a follow-up duration of 7-16 years, 3155 lung cancer cases (1777 men and 1378 women) under 3999765 participants.

Results and conclusions:
The researchers found that eating a lot of beta carotene (highest quintile compared with lowest quintile) the chances of getting lung cancer does not significantly with 2% [95% CI = 0.87-1.11] reduced. Not significant is, there is no link to a 95% reliability.

The researchers found that eating a lot of beta-cryptoxanthin (highest quintile (> 160 mcg per day) compared to lowest quintile ( 40 mcg/day)) the chances of getting lung cancer significantly with 24% [95% CI = 0.67-0.86] reduced. Significant is, there is a link at a 95% reliability. This reduced risk did not change after correcting for the intake of vitamin C, folate, other carotenoids and the use of multivitamin supplements.
These associations remained the same among non-, ex-and current smokers.

The researchers concluded that eating a lot of beta-cryptoxanthin (> 160 mcg per day) reduced the chance of getting lung cancer.

Original title:
Dietary Carotenoids and Risk of Lung Cancer in a Pooled Analysis of Seven Cohort Studies by Männistö S, Smith-Warner SA, [...], Hunter DJ.

Link:
http://cebp.aacrjournals.org/content/13/1/40.short

Additional information about El Mondo:
Beta-cryptoxanthin is a carotenoid.

Food And Beverages

How many beta-cryptoxanthin (mcg)

Khaki (100 grams)

1447

Mandarins (100 grams)

787

Papaya (100 grams)

545

Passion fruit (100 grams)

370

Dried currants (100 grams)

195

Red raw peppers (100 grams)

187

Sugar melon (100 grams)

161

Orange (100 grams)

135

Guava (100 grams)

110

Raw corn salad (100 g)

100

Apricots with Peel (100 grams)

91

Dried apricots (100 grams)

75

Cooked spinach (100 grams)

57

160 mcg beta cryptoxanthin per day thus corresponds with 145 grams raw corn salad.

The most important cause of lung cancer is smoking.

10 gram wortelen per dag verlaagt waarschijnlijk prostaatkanker

Research Question:
Previous studies into the relationship between eating carrots and let the risk of getting prostate cancer see inconsistent results. It was therefore carried out this review article.

Eating carrots lowers the chances of getting prostate cancer?

Study Design:
This overview article contained cohort studies.
There was no publication bias (Begg's funnel plot (p = 1,000) and Egger test (p = 0.804)).

Results and conclusions:
The researchers found that eating carrots significantly the chance of getting prostate cancer by 18% [OR = 0.82, 95% CI = 0.70-0.97] reduced.

The researchers found that eating 1 serving of carrots a week the chances of getting prostate cancer significantly with 5% [OR = 0.95, 95% CI = 0.90-0.99] reduced.

The researchers found that every 10 grams of carrots per day the chances of getting prostate cancer significantly with 4% [OR = 0.96, 95% CI = 0.94-0.99] reduced.

The researchers concluded eating carrots the chance of getting prostate cancer probably reduced. Probably because this overview article contained little cohort studies and there was substantial heterogeneity between the studies.

Original title:
Dietary carrot consumption and the risk of prostate cancer by Xu X, Cheng Y, [...], Xie L.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24519559

Additional information about El Mondo:
Find here more studies on carotenoids.

Een hoge vitamine E-bloedwaarde verlaagt prostaatkanker

Research Question:
Epidemiological studies that the association between the blood values of α-tocopherol and γ-tocopherol (the most important bioactive form of vitamin E) and the risk of prostate cancer have explored, let see inconsistent results. In addition, a quantitative assessment of published studies is not available. It was therefore carried out this review article.

Lowers high blood vitamin E-value the chance of getting prostate cancer?

Study Design:
This overview article 9 contained nested case-control studies from different countries with 370000 participants (4004 cases and 6890 controls).
The overall quality of all studies was okay.
The Egger test did not permit a publication bias for α-tocopherol-blood values (p = 0.08) or γ-tocopherol-blood values (p = 0.08) see.
There was significant heterogeneity among the studies with gamma-tocopherol blood values (p = 0.008) but not with alpha tocopherol (α-tocopherol) blood values (p = 0.33).

Results and conclusions:
The researchers found compared to the lowest category, had the highest alpha-tocopherol category a significantly reduced risk of 21% [RR = 0.79, 95% CI = 0.68-0.91] for prostate cancer.

The researchers found compared to the lowest category, had the highest gamma-tocopherol category a non-significant reduced risk of 11% [RR = 0.89, 95% CI = 0.71-1.12] for prostate cancer. Non-significant is, there is no link to a 95% reliability.

The researchers found that every increase in alpha-tocopherol bloedwaarden with 25 mg/L, prostate cancer risk significantly by 21% [RR = 0.79, 95% CI = 0.69-0.91] reduced. Significant is, there is a link at a 95% reliability.

The researchers concluded that only a high alpha-tocopherol bloedwaarde reduced the chance of getting prostate cancer.

Original title:
Blood α-Tocopherol, γ-Tocopherol Levels and Risk of Prostate Cancer: A Meta-Analysis of Prospective Studies by Cui R, Liu ZQ and Xu Q.

Link:
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3965522/

Additional information about El Mondo:
Find here more studies on vitamin E.

Meer onderzoek nodig naar MS en vitamine D

Research Question:
Swallowing vitamin D lowers the chances of getting multiple sclerosis?

Study Design:
The overview article contained 5 Rcts. The studies were small (23 to 68 patients). There was heterogeneity between the dosages, the form of vitamin D (4 Rcts with vitamin D3 and 1 with vitamin D2) and clinical outcome measures. Because of the poor study design could there is no meta-analysis carried out. A meta-analysis can show the size of the effect.

Results and conclusions:
Of the 5 Rcts found 4 no effect between vitamin D and each outcome of multiple sclerosis. 1 Rcts found a significant effect, namely a reduction in the number of T1 elevated lesions on the MRI scan of the brain. 3 Rcts found undesirable effect, especially intestinal and stomach discomfort in swallowing of vitamin D.

The researchers concluded that the evidence for vitamin D as a treatment for MS was unclear. Larger studies (Rcts with a follow-up duration of longer than 1 year) are necessary to the effect of vitamin D on the clinical outcomes in patients with MS to investigate.

Original title:
A Systematic Review of Randomized, Double-Blind, Placebo-Controlled Trials Examining the Clinical Efficacy of Vitamin D in Multiple Sclerosis by Pozuelo-Moyanoa B, Benito-Leóna J [...], Hernández-Gallegoa J.

Link:
http://content.karger.com/ProdukteDB/produkte.asp?Doi=345122

Additional information about El Mondo:
Multiple sclerosis (MS) is an inflammatory disease. In MS causes a disordered immune system inflammation in the brain and spinal cord. In doing so creates lasting damage to the myelin and axons, which account for a large part of the MS-complaints caused.

Multiple sclerosis is common among young adults, in women more than in men. The frequency in which the disease occurs, varies by country and population group. MS does not or hardly in countries closer to the equator.

The exact cause of MS is unknown, but it is widely believed that MS is caused by a combination of genetic and environmental factors.

 

 

20 microgram vitamine D per dag verlaagt fracturen bij ouderen

Research Question:
The results of the meta-analyses on the relationship between vitamin D supplementation and reducing fractures are inconsistent. It was therefore carried out this review article.

Swallowing of 800 IU of vitamin D lowers the chances of getting hip fractures and non-vertebral fractures in the elderly?

Study Design:
This overview article contained 11 Rcts with 31022 persons (average age of 76 years, 91% women) with 1111 incidental non-vertebral fractures and hip fractures 3770.

Results and conclusions:
The researchers found that swallowing average 800 IE (20 micrograms) of vitamin D per day the chances of getting hip fractures significantly reduced by 30%. The hazard ratio was 0.70 [95% CI = 0.58-0.86]. Significant is, it can be said with 95% reliability that the reduced risk of 30% was due to swallowing average 800 IU of vitamin D per day.

The researchers found that swallowing average 800 IE (20 micrograms) of vitamin D per day the chances of getting non-vertebral fractures significantly reduced by 14%. The hazard ratio was 0.86 [95% CI = 0.76-0.96]. Significant because 1 was not in the 95% CI of 0.76-0.96.

The researchers found that the daily swallowing of vitamin D (less than 800 IU) compared to not swallow daily of vitamin D the chances of getting hip fractures non-significant reduced by 10%. The hazard ratio was 0.90 [95% CI = 0.80-1.01]. Non-significant is, it cannot be said with 95% reliability that the reduced risk of 10% was due to the daily swallowing of vitamin d. non-significant means no link.

The researchers found that the daily swallowing of vitamin D (less than 800 IU) compared to not swallow daily of vitamin D the chances of getting non-vertebral fractures significantly reduced by 7%. The hazard ratio was 0.93 [95% CI = 0.87-0.99].

The researchers concluded that the daily swallowing of 800 IU of vitamin D per day or more the chance of getting hip fractures and non-vertebral fractures in people 65 years or older did decrease.

Original title:
A Pooled Analysis of Vitamin D Dose Requirements for Fracture Prevention by Bischoff-Ferrari HA, Willett WC, [...], Dawson-Hughes B.

Link:
http://www.nejm.org/doi/full/10.1056/NEJMoa1109617

Additional information about El Mondo:
Scientific studies show that blood to desired values of to get 75-80 nanomol/l 800-1200 IU of vitamin D per day is needed.
40 IU vitamin D equals 1 micrograms of vitamin d. So 1200 IE than 1200/40 = 30 micrograms of vitamin D per day.

Read more about vitamin D vitamin D in the presentation.

 

Vitamine D-supplementen verlagen niet borstkanker onder postmenopauzale vrouwen

Research Question:
Taking vitamin D supplements lowers the chance of getting breast cancer among postmenopausal women?

Study Design:
This overview article contained 2 RCTs with 5372 postmenopausal women.
There was no heterogeneity (p = 0.59, I2 = 0%).  

The daily dose was 800 IE (20 micrograms) vitamin D and 1000 mg of calcium for 24-62 months in one study and 1100 IE (27.5 micrograms) vitamin D and 1400 mg calcium citrate or calcium carbonate 1500 mg or in the other study.

Results and conclusions:
The researchers found that taking vitamin D supplements the chance of getting breast cancer among postmenopausal women not significantly by 11% [95% CI = 0.74-1.68] increased. Not significant is, there is no link to a 95% reliability

The researchers found that taking vitamin D supplements with the highest dosage, the chance of getting breast cancer among postmenopausal women not significantly with 42% [95% CI = 0.23-1.47] reduced. Not significant because the risk of 1 is in the 95% CI of 0.23 and 1.47. Risk of 1 means no risk.

The researchers found that taking vitamin D supplements in combination with calcium, the chance of getting breast cancer among postmenopausal women not significantly with 7% [95% CI = 0.54-1.60] reduced. Not significant is, there is no link to a 95% reliability

The researchers concluded that taking vitamin D supplements the chance of getting breast cancer among postmenopausal women not reduced. However, the available evidence is still limited and insufficient to draw firm conclusions.

Original title:
Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials by Sperati F, Vici P, [...], Barba M.

Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069269

Additional information about El Mondo:
Find here more studies on vitamin d.

 

Een hoog vitamine D bloedniveau verlaagt suikerziekte type 2

Research Question:
A high blood vitamin D level lowers the chances of getting diabetes type 2?

Study Design:
This overview article contained 21 prospective cohort studies with participants, of which 76220 4996 people with diabetes type 2.

Results and conclusions:
The researchers found that the highest 25 (OH) D vitamin D blood level compared to the lowest, the chances of getting type 2 diabetes significantly with 38% [95% CI = 0.54-0.70] reduced.

The researchers found in a spline regression model that a higher 25 (OH) D vitamin D blood level monotonous was associated with a lower risk of type 2 diabetes. This reduced risk was not dependent on gender, duration of the follow-up, the sample size, the diagnostic criteria of diabetes or the determination method of 25 (OH) D vitamin D blood level.

The researchers found that every increase of the 25 (OH) D vitamin D blood level with 10 nmol/L, the chance of getting type 2 diabetes significantly with 4% [95% CI = 3–6, P for linear trend 0.0001] reduced.

On the basis of the found results the researchers concluded that a high 25 (OH) D vitamin D blood level the chances of getting diabetes type 2 reduced.

Original title:
Blood 25-Hydroxy Vitamin D Levels and Incident Type 2 Diabetes: A meta-analysis of prospective studies by Song Y, Wang L, [...], Hu FB.

Link:
http://care.diabetesjournals.org/content/36/5/1422.short

Additional information about El Mondo:
Each 100 IU (2.5 mcg) Vitamin D3 can after 2 to 3 months swallow the blood value of 25 (OH) D with 1 ng/mL (2.5 nmol/L) increase. 1 ng/mL = 2.5 nmol/L 1 mcg = 40 IU of vitamin d.
An increase of 10 nmol/L corresponds to 400 IU of vitamin D for 2-3 months.

Read more about vitamin d.

 

Vitamine D-supplementen verlaagt niet suikerziekte type 2

Research Question:
Observational studies report a consistent association between low vitamin D blood concentration and increased blood sugar and the risk of getting type 2 diabetes, but the results in Rcts are contradictory and therefore was carried out this review article.

Swallowing vitamin D lowers the chances of getting diabetes type 2?

Study Design:
This overview article contained 35 Rcts with 43407 patients.

There was no question of publication bias.

Results and conclusions:
The researchers found that taking vitamin D had no significant effect on insulin resistance, expressed as HOMA-IR [MD =-0.04, 95% CI =-0.30 to 0.22, I2 = 45%].

The researchers found that taking vitamin D had no significant effect on insulin secretion, expressed as HOMA-B [MD = 1.64, 95% CI =-25.94 to 29.22, I2 = 40%].

The researchers found that taking vitamin D had no significant effect on the HbA1c value [MD =-0.05%, 95% CI =-0.12 to 0.03, I2 = 55%].

The researchers concluded that swallowing of vitamin D the chances of getting diabetes type 2 is not reduced.

Original title:
Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis by Seida JC, Mitri J, [...] Johnson, Yes.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/25062463

Additional information about El Mondo:
Find here more studies on vitamin d.

 

Vitamine D-supplementen verlaagt niet suikerziekte type 2

Research Question:
Observational studies report a consistent association between low vitamin D blood concentration and increased blood sugar and the risk of getting type 2 diabetes, but the results in Rcts are contradictory and therefore was carried out this review article.

Swallowing vitamin D lowers the chances of getting diabetes type 2?

Study Design:
This overview article contained 35 Rcts with 43407 patients.

There was no question of publication bias.

Results and conclusions:
The researchers found that taking vitamin D had no significant effect on insulin resistance, expressed as HOMA-IR [MD =-0.04, 95% CI =-0.30 to 0.22, I2 = 45%].

The researchers found that taking vitamin D had no significant effect on insulin secretion, expressed as HOMA-B [MD = 1.64, 95% CI =-25.94 to 29.22, I2 = 40%].

The researchers found that taking vitamin D had no significant effect on the HbA1c value [MD =-0.05%, 95% CI =-0.12 to 0.03, I2 = 55%].

The researchers concluded that swallowing of vitamin D the chances of getting diabetes type 2 is not reduced.

Original title:
Effect of Vitamin D3 Supplementation on Improving Glucose Homeostasis and Preventing Diabetes: A Systematic Review and Meta-Analysis by Seida JC, Mitri J, [...] Johnson, Yes.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/25062463

Additional information about El Mondo:
Find here more studies on vitamin d.

 

Een hoge vitamine D bloedwaarde verlaagt bloeddruk

Research Question:
High vitamin D blood value lowers the chances of getting high blood pressure?

Study Design:
This overview article contained 8 prospective cohort studies with 55816 283537 participants and people with high blood pressure. The study duration ranged between 1 and 14 years.

There was no heterogeneity between the studies.

Results and conclusions:
The researchers found in 5 studies that increasing the vitamin D blood value per 10 ng/mL compared to the baseline, the chances of getting high blood pressure significantly with 12% [95% CI = 0.81-0.97] reduced.

The researchers concluded that high vitamin D blood value the chance of getting high blood pressure lowered.

Original title:
Vitamin D and risk of future hypertension: meta-analysis of 283,537 participants by Kunutsor SK, Antoinette Apekey TA and Sturgeon M.

Link:
http://link.springer.com/article/10.1007/s10654-013-9790-2

Additional information about El Mondo:
The best way to get enough vitamin D is through sunlight and/or dietary supplements.
Find here more studies on vitamin d.

 

Vitamine D-gehalte boven 75 nmol/L verbetert de overlevingskansen van zowel patiënten met dikke darmkanker als borstkanker

Research Question:
Is there a relationship between the serum vitamin D levels and survival rates among both colon cancer and breast cancer patients?

Study Design:
This overview article contained 5 prospective cohort studies with cancer patients and borskankerpatiënten 2330 thick 4413.

Results and conclusions:
The researchers found that a high serum vitamin D levels the total mortality (death to) under thick darmkankerpatitënten significantly with 29% [95% CI = 0.55-0.91] reduced.

The researchers found that a high serum vitamin D levels the colon cancer-related mortality among thick darmkankerpatitënten significantly with 35% [95% CI = 0.49-0.86] reduced.

The researchers found that a high serum vitamin D levels the total mortality among borskankerpatiënten significantly with 38% [95% CI = 0.49-0.78] reduced.

The researchers found that a high serum vitamin D levels the breast cancer-related mortality among borskankerpatiënten significantly with 42% [95% CI = 0.38-0.84] reduced.

The researchers concluded that a higher serum vitamin D levels (> 75 nmol/L) the mortality (death to) under both patients with colon cancer as breast cancer reduced. Randomized and controlled trials (Rcts) are needed to assess whether vitamin D supplementation survivability under both colon and breast cancer patients with lower vitamin D levels ( 50 nmol/L) in diagnosis and for treatment, can improve.

Original title:
Serum 25-hydroxyvitamin D levels and survival-in colorectal and breast cancer patients: Systematic review and meta-analysis of prospective cohort studies by JM, Maalmi H, Ordóñez-Mena [...], Brenner H.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24582912

Additional information about El Mondo:
Find here more studies on vitamin d.

Een vitamine D-bloedwaarde lager dan 50 nmol/L tijdens de zwangerschap verhoogt pre-eclampsie, zwangerschapdiabetes, een vroeggeboorte en een SGA-baby

Research Question:
Increases low vitamin D blood value during pregnancy the chance of getting preeclampsia, gestational diabetes, a premature birth or a SGA baby?

Study Design:
This overview article contained 24 observational studies.

Results and conclusions:
The researchers found that a vitamin D blood value is less than 50 nmol/L during pregnancy, the chances of getting preeclampsia (pregnancy toxaemia) significantly with 109% [95% CI = 1.50-2.90] increased. Significant is, there is a link at a 95% reliability.

The researchers found that a vitamin D blood value is less than 50 nmol/L during pregnancy, the chances of getting gestational diabetes significantly with 38% [95% CI = 1.12-1.70] increased.

The researchers found that a vitamin D blood value is less than 50 nmol/L during pregnancy, the chances of getting a premature birth significantly with 58% [95% CI = 1.08-2.31] increased.

The researchers found that a vitamin D blood value is less than 50 nmol/L during pregnancy, the chances of getting an SGA baby significantly with 52% [95% CI = 1.08-2.15] increased.

The researchers concluded that a vitamin D blood value is less than 50 nmol/L during pregnancy the chance of getting preeclampsia, gestational diabetes, a premature birth and SGA baby increased.

Original title:
Maternal vitamin D status and adverse pregnancy outcomes: a systematic review and meta-analysis by Wei SQ, Qi HP, [...], Fraser WD.

Link:
http://informahealthcare.com/doi/abs/10.3109/14767058.2013.765849?journalCode=jmf

Additional information about El Mondo:
Read more about studies on vitamin d.

Vitamine C-supplementen verlagen op korte termijn de bloeddruk

Research Question:
In observational studies, an increased intake of vitamin C, vitamin C supplementation and high vitamin C blood concentration are associated with low blood pressure. But the instructions for blood pressure-lowering effects of vitamin C in clinical studies have been inconsistent. Therefore it was the aim of this systematic review and meta-analysis of clinical trials to the effects of vitamin C supplementation on blood pressure to investigate.

Can vitamin C supplements lower blood pressure?


Study Design:
This overview article contained 29 Rcts with an average duration of 8 weeks and 10 to 120 participants per study. Only Rcts can show a causal link.

Results and conclusions:
The researchers found that taking vitamin C supplements (on average 500 mg per day) the systolic pressure (systolic blood pressure) significantly with 3.84 mmHg [95% CI =-5.29 to-2.38 mm Hg, p 0.01] did decrease. Significant is, it can be said with 95% reliability that the short-lived swallowing vitamin C supplements reduced the peak pressure really.

The researchers found that taking vitamin C supplements (on average 500 mg per day) the diastolic pressure (underpressure) significantly with 1.48 mmHg [95% CI =-2.86 to-0.10 mmHg, p = 0.04] did decrease. Significant because the p-value was less than 0.05.

Methypertensieve participants in studies the researchers found that taking vitamin C supplements (on average 500 mg per day) the systolic pressure significantly with 4.85 mmHg [p 0.01] did decrease.


Methypertensieve participants in studies the researchers found that taking vitamin C supplements (on average 500 mg per day) the diastolic pressure non-significant with 1.67 mmHg [p 0.17] did decrease. Non-significant means no link.

The researchers concluded that the short-lived swallowing vitamin C supplements (500 mg per day with an average duration of 8 weeks) the blood pressure lowered but research is needed into the effect of the prolonged swallow vitamin C supplements on blood pressure.

Original title:
Effects of vitamin C supplementation on blood pressure: a meta-analysis of randomized controlled trials by Juraschek SP, Guallar E, [...], Miller THERE.

Link:

http://www.ajcn.org/content/95/5/1079.short

Additional information about El Mondo:
The optimal blood pressure for a healthy adult person is 120 mmHg systolic blood pressure and 80 mmHg vacuum.


It is not possible through feeding 500 mg of vitamin C per day to get inside. 200-300 g of vegetables and 2-5 pieces of fruit per day on average 200 mg vitamin C on.

 

500 mg vitamine C per dag verlaagt het cholesterolgehalte bij mensen met hoog cholesterolgehalte

Research Question:
Swallowing of vitamin C lowers cholesterol levels in people with high cholesterol?

Study Design:
This overview article contained 13 Rcts. The age of the participants ranged from 48 to 82 years.

The dosage of vitamin C was not less than 500 mg daily for 3 to 24 weeks.
The participants in the intervention group at the beginning of the study had a cholesterol content of 163.7 mg/dL and in the control group was that 154.6 mg/dL.

There was heterogeneity because the random effect model was used but no publication bias.

Results and conclusions:
The researchers found (in 11 Rcts with 328 people in the intervention group and 310 in the control group, average age was 58.9 years) that taking vitamin C for 10 weeks the LDL cholesterol (bad cholesterol) significantly with 7.9 mg/dL or 5% [95% CI = − 12.3 to − 3.5, p = 0.000] reduced.
Significant is, there is a link at a 95% reliability.

The researchers found (in 12 Rcts with 355 people in the intervention group and 338 in the control group, average age was 60.8 years) that taking vitamin C for 10 weeks the HDL cholesterol (good cholesterol) non-significant with 1.1 mg/dL or 2.3% [95% CI = − 0.2 to 2.3] increased.
Non-significant is, there is no link to a 95% reliability.

The researchers found (in 10 Rcts with 289 people in the intervention group and 270 in the control group, average age was 55.7 years) that taking vitamin C for 8 weeks the triglyceride levels significantly with 20.1 mg/dL or 8.8% [95% CI = − 33.3 to − 6.8, p 0.003] reduced. Significant is, there is a link at a 95% reliability.

The researchers found that taking vitamin C the LDL/HDL ratio with 0.60 or 16.2% reduced. 16.2% reduction corresponds to a reduced chance of 10.2% of getting heart disease.

The researchers found that taking vitamin C the triglycerides/HDL ratio with 0.47 or 9.4% reduced.

The researchers concluded that swallowing of at least 500 mg of vitamin C per day for 8-10 weeks, LDL cholesterol and triglyceride levels of people with high cholesterol levels reduced.

Original title:
Vitamin C supplementation Dar serum low-density lipoprotein cholesterol and triglycerides: a meta-analysis of randomized controlled trials by McRae 13 MP.

Link:
 http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2682928/

Additional information about El Mondo:
Read more about cholesterol and vitamin C.
It is not possible to use nutrition to get 500 mg of vitamin C within.

Optimal LDL cholesterol is 100 mg/dL.
Cholesterol levels can differ from day to day about 10 percent.
Desired total cholesterol/HDL ratio is below 5: 1; optimal is below 3.5: 1.
LDL cholesterol/HDL ratio is below 5: 1; optimal is below 3.5: 1.
HDL cholesterol/LDL ratio you want is above 0.3; optimal above 0.4.
The cholesterol ratio is a better predictor for heart disease than total cholesterol value.

The higher the LDL cholesterol and triglyceride levels, the higher the risk of heart disease is.
The higher the HDL cholesterol levels, the lower the risk of heart disease is. HDL cholesterol provides transport of cholesterol from the arterial wall to the liver. The higher the HDL-cholesterol, the better is the drainage of excess cholesterol to the liver.

 

500-2000 mg vitamine C verlaagt mogelijk inspanningsastma

Research Question:
Vitamin C reduces the effort of swallowing-induced bronchoconstriction (exercise-induced asthma)?

Study Design:
This overview article contained 3 Rcts with 40 participants.
There was no heterogeneity (I2 = 0%) because the fixed effect model was used.
The dosage of vitamin C was 0.5-2 grams for 1 day or for several days. The average age in 1 study was 14 years and 25 and 26 years in other 2 studies.

Results and conclusions:
The researchers found that taking vitamin C just before the effort the chance of getting the effort-induced bronchoconstriction significantly reduced. The decrease in post effort FEV1 (forced expiratory volume in FEV1 = 1 sec) decreased significantly with 8.4% [95% CI = 4.6-12%, p 0.001].

The researcher concluded that people who suffer from effort-induced bronchoconstriction as possible helped in swallowing of 500-2000 mg of vitamin C just before the effort. Possible because there are too few studies were available and the studies also contain few participants.

Original title:
Vitamin C may alleviate exercise-induced bronchoconstriction: a meta-analysis by Hemilä H.

Link:
http://bmjopen.bmj.com/content/3/6/e002416.full

Additional information about El Mondo:
Read more about vitamin C.
It is not possible through feeding 500 mg of vitamin C to get inside.

200 mg vitamine C per dag verkort de duur van een verkoudheid

Research Question:
Swallowing of vitamin C lowers the chances of getting a cold?

Study Design:
This overview article contained 29 Rcts with 11306 participants.

The dosage of vitamin C was at least 200 mg per day.

Results and conclusions:
The researchers found that taking vitamin C in the ordinary population the chance of getting a cold non-significant with 3% [95% CI = 0.94-1.00] reduced. Non-significant is, there is no link to a 95% reliability.

The researchers found in 5 Rcts with 598 participants who performed physical efforts, that swallowing of vitamin C the chance of getting a cold significantly with 52% [95% CI = 0.35-0.64] reduced. Significant is, there is a link at a 95% reliability.

The researchers found that taking vitamin C the duration of colds in adults was significantly sho[95% BI = 3-12%] rtened by 8% and 14% in children[95% BI = 7-21%].

The researchers found that swallowing 1-2 grams of vitamin C per day the duration of colds in children significantly shortened by 18%. Significant is, there can be said with a 95% reliability that swallowing 1-2 grams of vitamin C per day really shortened the duration of colds in children.

The researchers concluded that swallowing at least 200 mg of vitamin C per day the chances of getting a cold only in people who have physical efforts (marathon runners, skiers and soldiers on subarctic exercises) performed, lowered. Further reduced swallowing at least 200 mg of vitamin C per day the duration of a cold.

Original title:
Vitamin C for preventing and treating the common cold by Chalker Hemilä H and E.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/23440782

Additional information about El Mondo:
Read more about vitamin C.
200-300 g of vegetables and 2-5 pieces of fruit per day on average 200 mg vitamin C.
This meal delivers 210 mg of vitamin C.

An overview article of Rcts answers the following question: "Is swallowing food supplements make sense?"
A review article is a collection of so far available scientific articles about a certain subject.

500 mg vitamine C per dag voorkomt complex regionaal pijn syndroom na een zware operatie of letsel

Research Question:
Swallowing of vitamin C lowers the chances of getting complex regional pain syndrome (CRPS) after surgery or injury?

Study Design:
This overview article contained 4 Rcts. 
The dosage of vitamin C was not less than 500 mg a day for 45-50 days. There was no heterogeneity.

Results and conclusions:
The researchers found that swallowing a minimum of 500 mg of vitamin C per day for 45-50 days right after a major surgery or injury, the chances of getting complex regional pain syndrome significantly with 78% [RR = 0.22, 95% CI = 0.12-0.39] reduced. Significant is, there is a link at a 95% reliability.

The researchers concluded that the routine at least 500 mg daily swallowing vitamin C, the chances of getting complex regional pain syndrome after a major surgery (a foot or ankle surgery) or injury reduced.

Original title:
Efficacy and safety of high-dose vitamin C on complex regional pain syndrome in extremity trauma and surgery--systematic review and meta-analysis by Shibuya N, Humphers JM, [...], Jupiter DC.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/22985495

Additional information about El Mondo:
Read more about vitamin C.
200-300 g of vegetables and 2-5 pieces of fruit per day on average 200 mg vitamin C.
It is not possible 500 mg of vitamin C to get through nutrition.

Complex regional pain syndrome (CRPS) is (chronic) pain disorder characterized by pain and changes in color and temperature of the skin. There is also often involve swelling. Other symptoms that may occur include movement restrictions, a change in the sweat pattern, cramping of hands and feet (Dystonia) and changes in skin, hair and nail growth.

CRPS is a condition that occurs at all ages, but more often in people between 45 and 60 years and more in women (75%) than in men.

 

Het eten van veel vitamine C en beta-carteen verlaagt dikke darm adenoom

Research Question:
Eating vitamins lowers the chances of getting colon adenoma?  

Study Design:
This overview article contained 13 observational studies with 3832 people with colon adenoma.

Results and conclusions:
The researchers found that eating a lot of vitamin C compared to little, the chance of getting colon adenoma significantly with 22% [95% CI = 0.62-0.98] reduced. The reduced risk did not change by BMI, the smoking behaviour and the energy intake.

The researchers found that eating a lot of beta carotene compared with little, the chance of getting colon adenoma also significantly reduced. But the reduced risk was not found for eating a lot of vitamin A [pooled RR = 0.87, 95% CI = 0.67-1.14] and vitamin E [pooled RR = 87, 95% CI = 0.69-1.10].

The researchers concluded that eating a lot of vitamin C and beta-carteen the chance of getting colon adenoma reduced.

Original title:
Dietary intake of vitamins A, C, and E and the risk of colorectal adenoma: a meta-analysis of observational studies by Xu X, Yu E, [...], Fu C.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24064545

Additional information about El Mondo:
A good way to daily a lot of vitamin C and beta-carotene to get inside, through 200-300 g of vegetables, especially paprika and dark green leafy vegetables (spinach) and 2-5 pieces of fruit, especially felgekeurde fruits per day.
Find here more studies on vitamin C and beta-carotene.

That eating a lot of vitamin C and beta-carteen the chance of getting colon adenoma lowers, does not say it is justified now to vitamin C and beta carotene supplements to go swallow in the fight against colon adenoma. A power supply with lots of vitamin C and beta carotene is certainly not the same as swallowing vitamin C and beta carotene supplements. You can compare this with the following example: a monkey is an animal but not every animal is a monkey!

 

100 mg vitamine C via voeding verlaagt doodgaan aan borstkanker

Research Question:
Total vitamin C intake reduces and breast cancer-related mortality?

Study Design:
This overview article contained 10 studies (vitamin C supplements (n = 6) and vitamin C through feeding (n = 7)) with 17696 patients with breast cancer and kill, which have gone to 2791 1558 breast cancer death.

Results and conclusions:
The researchers found that the use of vitamin C supplements after the diagnosis of breast cancer, the risk of total mortality significantly with 19% [95% CI = 0.72-0.91] reduced.

The researchers found that the use of vitamin C supplements after the diagnosis of breast cancer, the risk of breast cancer-related mortality significantly with 15% [95% CI = 0.74-0.99] reduced.

The researchers found that each increase of 100 mg vitamin C through feeding, the risk of total mortality significantly with 27% [95% CI = 0.59-0.89] reduced.

The researchers found that each increase of 100 mg vitamin C through feeding, the risk of breast cancer-related mortality significantly with 22% [95% CI = 0.64-0.94] reduced.

The researchers concluded that vitamin C reduced breast cancer-related mortality total as well.

Original title:
Vitamin C and survival among women with breast cancer: A Meta-analysis by Harris HR, Orsini N and Cloud A.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24613622

Additional information about El Mondo:
Find here more studies on vitamin C.
 

 

Een hoog homocysteïnegehalte verhoogt mogelijk fracturen bij ouderen

Research Question:
Is there a link between vitamin B12, folate and homocysteine levels and the risk of fractures in the elderly?

Study Design:
This overview article contained observational studies until July 2012. The age of the participants in the studies ranged from 41 to 78 years.

Results and conclusions:
The researchers found in 4 observational studies with 7475 elderly, of which 458 cases with fractures and a follow up duration from 3 to 16 years, that any increase in the plasma/serum vitamin B12 levels with 50 picomol/L the chance of getting fractures with non-significant 4% [95% CI = 0.92-1.00, there was no heterogeneity between the studies] reduced.
Non-significant is, there is no link to a 95% reliability but a trend.

The researchers found in 8 observational studies with 11511 elderly, whose 1353 cases with fractures and a follow up duration from 3 to 12.6 years, that any increase in homocysteine levels the chance of getting fractures significantly with 4% [95% CI = 1.02-1.07, there was a great heterogeneity between the studies] increased.

The researchers found no relationship between vitamin B12, folate and homocysteine levels and bone density in women.

The researchers concluded that high homocysteine levels increased the chance of getting invoices as possible. Possible because there was heterogeneity between the studies.

Original title:
Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses by Vincent JP, Deleon EL, [...], de Groot.

Link:
http://www.hindawi.com/journals/jnume/2013/486186

Additional information about El Mondo:
Homocysteine levels of healthy men is 13-14 µmol/litre and by healthy women is 12-13 µmol/litre. A high homocysteine levels (> 15 µmol/l) is also a risk factor for heart disease. The high homocysteine levels can effectively be reduced with 500 micrograms of folic acid supplements per day. The high homocysteine levels cannot be lowered with vitamin B6 and B12. However, sufficient folic acid, vitamin B6 and B12 via food can prevent a high homocysteine levels. Sufficient to say it covers the recommended daily allowance.

Observational studies include cohort studies and case-control studies.

Het slikken van vitamine B6, B12 en foliumzuur verbetert niet het cognitief vermogen van ouderen

Research Question:
An increased plasma homocysteine levels is associated with getting cognitive impairment and dementia in later life but an increased plasma homocysteine levels can be lowered by daily swallowing of vitamin B6, B12 and folic acid.

Can swallowing vitamin B6, B12 and folic acid to improve the cognitive ability of the elderly?

Study Design:
This overview article contained 19 Rcts.

Results and conclusions:
Taking B vitamins (vitamin B6, B12 and folic acid) showed no significant improvement in cognitive ability in persons with [SMD = 0.10, 95% CI =-0.08 to 0.28] or without [SMD =-0.03, 95% CI =-0.1 to 0.04] significant cognitive impairment.

Found this result was independent of the study duration [SMD = 0.05, 95% CI =-0.10 to 0.20 and SMD = 0, 95% CI =-0.08 to 0.08], the study size (SMD = 0.05, 95% CI =-0.09 to 0.19 and SMD =-0.02, 95% CI =-0.10 to 0.05] and whether participants came from countries with a low folate status [SMD = 0.14, 95% CI =-0.12 to 0.40 and SMD =-0.10, 95% CI =-0.23 to 0.04].

The researchers concluded that swallowing of vitamin B6, B12 and folic acid alone or in combination the cognitive ability in older adults with or without existing cognitive impairment, not improved. But it still needs to be determined whether long-term treatment with B-vitamins may reduce the risk of dementia later in life.

Original title:
Effect of Homocysteine lowering Treatment on Cognitive Function: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Ford AH and Almeida on.

Link:
http://iospress.metapress.com/content/m42p8130lq7hk785

Additional information about El Mondo:
Daily physical activities and think games can improve cognitive ability in the elderly.