Calciuminname tot boven 1000 mg per dag verlaagt dikke darmkanker

Research Question:
Calcium intake lowers the chances of getting colon cancer?

Study Design:
This overview article contained observational prospective studies.

Results and conclusions:
The researchers found in 15 studies (12305 patients with colon cancer. The calcium intake was 250-1900 mg/day and the follow-up duration was 3.3-16 years), that every 300 mg calcium (through feeding and nutritional supplements) per day, the chances of getting colon cancer significantly with 8% [RR = 0.92, 95% CI = 0.89-0.95, I2 = 47%] reduced.

The researchers found in 6 studies (8839 patients with colon cancer, calcium intake = 0-1150 mg/day and follow-up duration = 5-10 years] that every 300 mg of calcium from dietary supplements a day, the chances of getting colon cancer significantly with 9% [RR = 0.91, 95% CI = 0.86-0.98, I2 = 67%] reduced.

The researchers found that the test for non-linearity was not significant [p non-linearity = 0.11].

The researchers concluded that calcium intake (both through feeding as dietary supplements) to above 1000 mg per day, the chances of getting colon cancer reduced.

Original title:
Calcium intake and colorectal cancer risk: Dose-response meta-analysis of prospective observational studies by Keum N, Aune D, [...], Giovannucci EL.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/24623471

Additional information about El Mondo:
Find here more studies on calcium.