Een hoge foliumzuurinname verlaagt dikke darmkanker

Research Question:
The intake of folic acid lowers the chances of getting colon cancer (colon cancer)?

Study Design:
This overview article contained 13 prospective cohort studies with 725134 participants, of which 5720 cases with colon cancer. There was no question of heterogeneity between the studies.

Results and conclusions:
The researchers found that eating folic acid (the highest quintile versus the lowest quintile) the chances of getting colon cancer non-significant with 8% [95% CI = 0.84-1.00] reduced. Non-significant is, there is no link to a 95% reliability.

The researchers found that the intake of 560 or more micrograms of folic acid per day (via power supply and/or dietary supplements) compared to an intake of less than 240 micrograms per day, the chances of getting colon cancer significantly with 13% [95% CI = 0.78-0.98] reduced. Significant is, there is a link at a 95% reliability.

The researchers found that each increase of 100 micrograms of folic acid per day the chances of getting colon cancer reduced by 2%.

The researchers concluded that high folic acid intake the chance of getting colon cancer reduced.

Original title:
Pooled analyses of 13 prospective cohort studies on folate intake and colon cancer by Kim DH, Smith-Warner SA, [...], Hunter DJ.

Link:
http://link.springer.com/article/10.1007%2Fs10552-010-9620-8?LI=true

Additional information about El Mondo:
It is not possible per day to get 400 micrograms of folic acid through nutrition.