Een hoog homocysteïnegehalte verhoogt mogelijk fracturen bij ouderen

Research Question:
Is there a link between vitamin B12, folate and homocysteine levels and the risk of fractures in the elderly?

Study Design:
This overview article contained observational studies until July 2012. The age of the participants in the studies ranged from 41 to 78 years.

Results and conclusions:
The researchers found in 4 observational studies with 7475 elderly, of which 458 cases with fractures and a follow up duration from 3 to 16 years, that any increase in the plasma/serum vitamin B12 levels with 50 picomol/L the chance of getting fractures with non-significant 4% [95% CI = 0.92-1.00, there was no heterogeneity between the studies] reduced.
Non-significant is, there is no link to a 95% reliability but a trend.

The researchers found in 8 observational studies with 11511 elderly, whose 1353 cases with fractures and a follow up duration from 3 to 12.6 years, that any increase in homocysteine levels the chance of getting fractures significantly with 4% [95% CI = 1.02-1.07, there was a great heterogeneity between the studies] increased.

The researchers found no relationship between vitamin B12, folate and homocysteine levels and bone density in women.

The researchers concluded that high homocysteine levels increased the chance of getting invoices as possible. Possible because there was heterogeneity between the studies.

Original title:
Vitamin B12, Folate, Homocysteine, and Bone Health in Adults and Elderly People: A Systematic Review with Meta-Analyses by Vincent JP, Deleon EL, [...], de Groot.

Link:
http://www.hindawi.com/journals/jnume/2013/486186

Additional information about El Mondo:
Homocysteine levels of healthy men is 13-14 µmol/litre and by healthy women is 12-13 µmol/litre. A high homocysteine levels (> 15 µmol/l) is also a risk factor for heart disease. The high homocysteine levels can effectively be reduced with 500 micrograms of folic acid supplements per day. The high homocysteine levels cannot be lowered with vitamin B6 and B12. However, sufficient folic acid, vitamin B6 and B12 via food can prevent a high homocysteine levels. Sufficient to say it covers the recommended daily allowance.

Observational studies include cohort studies and case-control studies.