Een hoog maternaal homocysteïnegehalte verhoogt de kans op een SGA-baby

Research Question:
The total homocysteïneconcentraties during pregnancy are associated with a wide range of unwanted pregnancy outcomes and may possibly affect the birth weight.

Should women during pregnancy on their homocysteine levels look for?

Study Design:
This overview article contained 19 Rcts with 21326 participants.

Results and conclusions:
The meta-analysis showed a crude OR of 1.25 [95% CI = 1.09-1.44] see. By the crude OR as a linear effect to express it came in line with a decrease in the birth weight of 31 grams (95% CI =-13 to-51 grams) at a 1-SD increase in maternal homocysteine levels.

The researchers concluded that women who during pregnancy a high homocysteine levels had an elevated risk of getting an SGA baby or a baby with a low birth weight. The small estimated birth weight difference would have little clinical relevance to individual newborn but it would be of greater importance, however, are on the population level.

Original title:
Maternal homocysteine and small-for-gestational-age offspring: systematic review and meta-analysis by Hamed M, Blom HJ and DD M.

Link:
http://www.ajcn.org/content/95/1/130.short

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