Flavonoïden bieden bescherming tegen hart- en vaatziekten

Research Question:
Previous systematic review articles show beneficial effects of flavonoids on the biomarkers of coronary heart disease, but they don't have the impact of the dose-response or the nutritional complexity looked. The purpose of this review article was therefore to the relative effect of the composition, structure and to examine the amount of flavonoids.

 Lowering eating flavonoids chances of getting heart disease?

Study Design:
This review article examined the effects of six flavonoids subgroups on the endothelial function (flow-mediated dilation) and the systolic and diastolic blood pressure by means of random effects meta-analyses and regression analyses.

Results and conclusions:
The meta-analysis of combined flavonoids subgroups showed significant improvements in endothelial function see [chronic: 0.73%, 95% CI = 0.17-1.30, 14 Rcts; acute: 2.33%, 95% CI = 1.58-3.08, 18 Rcts].

The meta-analysis of combined flavonoids subgroups showed significant improvements in blood pressure see [systolic: 1.46 mmHg, 95% CI =-2.38 to 0.53, 63 Rcts; diastolic: 1.25 mmHg, 95% CI = 1.82 to 0.67, 63 Rcts].

Such benefits were also observed for the sub-groups of flavan-3-ol, catechol flavonoids (catechins, quercetin, cyanidin etc.), epicatechinen and catechins, Procyanidins.

The dose-dependent relationship was non-linear for the endothelial function (R2 ≤ 0.30) and there was no indication of a dose dependent connection for blood pressure.

The researchers concluded that the bioactivity (the operation) of flavonoids no classical linear dose dependent connection followed and this can give important biological implications.

Original title:
Relative impact of flavonoid composition, dose and structure on vascular function: A systematic review of randomised controlled trials of flavonoid-rich food products by CD Kay, Hooper L, [...], Cassidy a.


Additional information about El Mondo:
Read more about flavonoids flavonoids in the presentation.