Voedingsadvies El MondoResearch Question:
Scientific studies suggest that flavonoids have a chemopreventive effect on cancer. However the number of epidemiological studies, in which looks at the effect of flavonoids on getting breast cancer conflicting results on. It was therefore carried out this review article.
Lowers eating flavonoids the chance of getting breast cancer?
Study Design:
This overview article contained 6 prospective cohort studies and case-control studies 6. The studies gave 9513 together cases of breast cancer and breast cancer cases without 181906.
Results and conclusions:
The researchers found that women who ate a lot of flavonolen in 6 studies, ran significant 12% [95% CI = 0.80-0.98] less chance of getting breast cancer than women who ate little flavonolen. Significant is, there is a link at a 95% reliability.
The researchers found that women who ate a lot of flavones in 4 studies, ran significant 17% [95% CI = 0.76-0.91] less chance of getting breast cancer than women who ate little flavones.
The researchers found in 6 studies that women who ate a lot of flavan-3-OLS, ran non-significant 7% [95% CI = 0.84-1.02] less chance of getting breast cancer than women who ate little flavan-3-OLS. Non-significant is, there is no link to a 95% reliability. Non-significant would practically say, there is a trend but no connection.
The researchers found that women who ate a lot of flavanonen in 4 studies, ran non-significant 5% [95% CI = 0.88-1.03] less chance of getting breast cancer than women who ate little flavanonen.
The researchers found that women who ate a lot of anthocyanins in 3 studies, ran non-significant 3% [95% CI = 0.87-1.08] less chance of getting breast cancer than women who ate little anthocyanins. Non-significant is, there is no link to a 95% reliability but a trend.
The researchers found in 5 studies that women who ate a lot of (total) flavonoids, ran non-significant 2% [95% CI = 0.86-1.12] less chance of getting breast cancer than women who ate little (total) flavonoids.
In the subgroup-analyses (to get additional information), the researchers found a significant association between eating or flavan-3-OLS flavonolen, flavones and the reduced risk of getting breast cancer in postmenopausal women but not in pre-menopausal women.
The researchers concluded that eating flavonolen and flavones the chance of getting breast cancer, particularly in postmenopausal women reduced (after menopause).
Original title:
Flavonoids, Flavonoid Subclasses and Breast Cancer Risk: A Meta-Analysis of an epidemiological Studies by Chang H, Xie Q, [...], Mi M
Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0054318
Additional information about El Mondo:
The main sources of flavonolen and flavones are tea, wine and onions. Read more about flavonoids.