Geen verband tussen plantensterolen en hart- en vaatziekten

Research Question:
The impact of the increased serum concentrations of plant sterols on cardiovascular risk is unclear. Therefore, a systematic literature review and meta-analysis performed to investigate whether there is a link between the serum concentrations of two common plant sterols (sitosterol and campesterol) and the risk of cardiovascular disease (CVD).

Plant sterols content in the blood lowers the chances of getting heart disease?

Study Design:
This overview article contained 17 studies (4 case-control studies, 5 3 nested case-control studies, cohort studies and 5 cross-sectional studies) with 11182 participants.
8 studies reported the relative risk of cardiovascular disease and 15 studies the serum concentration of plant sterols. The average age was 48 to 78 years and there was talk of publication bias, suggesting it's not publishing small studies without significant results.

Results and conclusions:
The relative risk of the serum concentration campesterol was non-significant 1.02 [95% CI = 0.94-1.09, p = 0.675]. Non-significant means no link.

The relative risk of the serum concentration sitosterol was non-significant 1.06 [95% CI = 0.84-1.34, p = 0.644].

The researcher concluded that there was no evidence that there is a correlation between the serum concentration on plant sterols and the risk of heart disease.

Original title:
Plant sterols and cardiovascular disease: a systematic review and meta-analysis by Gabriel B, Silbernagel G, [...], März W.


Additional information about El Mondo:
90% of the plant sterols in nutrition and blood are sitosterol and campesterol.

The EFSA has the following claim of plant sterols/stanols-approved:
a daily intake of 3 (range 2.6-3.4) grams of plant sterols/stanols-lowers the LDL cholesterol by 11%.
EFSA considers that the minimum required expensive to the maximum effect of plant sterols/stanols on the LDL-cholesterol levels-is two to three weeks. This text is not on the package of the food!
From december 2012, the manufacturers still only approved claims of the EFSA on the food packaging and food supplements.

There is besides a high LDL-cholesterol levels have other risk factors that the chance of getting heart disease. In other words, eating products with added plant sterols/stanols-do not give the guarantee that cardiovascular disease occurs.
In products with added plant sterols/stanols are relationship-too much fat (> 35 and%) and saturated fat (> 10 and%). Fat and saturated fat are risk factors of heart disease.