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Research Question:
Although the evidence from cohort studies suggests that the intake of trans fatty acids may be associated with insulin resistance and diabetes, deliver Randomized placebo-controlled double-blind human studies (Rcts) conflicting results. This meta-analysis examined the role of the intake of trans fatty acids on glucose homeostasis (sugar balance).

Has eating trans fatty acids affect the sugar metabolism in the body?

Study Design:
This overview article contained 7 Rcts. There was no question of publication bias.

 

Results and conclusions:

The meta-analysis showed that an increased intake of trans fatty acids not resulted in a significant change of the sugar and insulin concentration in the blood.

An increased intake of trans fatty acids led to a significant increase in the total and LDL-cholesterol levels. The pooled effect size (ES) was respectively 0.28 [95% CI = 0.04-0.51] and 0.36 [95% CI = 0.13-0.60].

An increased intake of trans fatty acids led to a significant reduction in the HDL-cholesterol levels. The pooled effect size (ES) was respectively-0.25 [95% CI =-0.48 to-0.01].

There was no dose-dependent relationship between the pooled effect size and the intake of trans fatty acids.

The researchers concluded that an increased intake of trans fatty acids did not lead to changes in the glucose, insulin-or triglyceride concentrations, but it led to an increase in the total-and LDL-and a decrease in HDL-cholesterol levels. So there was no evidence for a possible benefit of the reduction of the intake of trans fatty acids on glucose homeostasis.

Original title:
Effects of trans fatty acids on glucose homeostasis: a meta-analysis of randomized, placebo-controlled clinical trials by Aronis KN, Khan SM and CS Mantzoros.

Link:

http://ajcn.nutrition.org/content/96/5/1093.abstract

Additional information about El Mondo:
Read more about the meta-analysis, cohort studies, study design RCT in the presentation and significance.

Read more about trans fatty acids in the presentation fats.

A high total and LDL-cholesterol levels and a high triglyceride concentration increase the chance of getting heart disease.
A high HDL-cholesterol levels lowers the chances of getting heart disease.