Het eten van flavonoïden verlaagt hart- en vaatziekten

Research Question:
Observational studies suggest that the intake of flavonoids is associated with a reduced risk of heart disease. However, the results of these studies are controversial. It was therefore carried out this review article.

Reduces the intake of flavonoids through feeding the chance of getting heart disease?

Study Design:
This overview article contained 14 prospective cohort studies.

Results and conclusions:
The researchers found that eating a lot of anthocyanidins compared with little, chances of getting heart disease significantly with 11% [RR = 0.89, 95% CI = 0.83-0.96] reduced.

The researchers found that eating a lot of Proanthocyanidins compared with little, chances of getting heart disease significantly with 10% [RR = 0.90, 95% CI = 0.82-0.98] reduced.

The researchers found that eating a lot of flavones compared with little, chances of getting heart disease significantly with 12% [RR = 0.88, 95% CI = 0.82-0.96] reduced.

The researchers found that eating a lot of flavanonen compared with little, chances of getting heart disease significantly with 12% [RR = 0.88, 95% CI = 0.82-0.96] reduced.

The researchers found that eating flavan-3-OLS compared with little, chances of getting heart disease significantly with 13% [RR = 0.87, 95% CI = 0.80-0.95] reduced.

Similar results were also found for flavonolen.
The sensitivity analyses and the subgroup analyses supported these associations.

The researchers found that every increase of 10 mg flavone (ipriflavone) per day the chance of getting heart disease significantly with 5% [95% CI = 0.91-0.99] reduced.

The researchers concluded that eating flavonoids (flavonolen, in particular anthocyanidins, Proanthocyanidins, flavones, flavanonen and flavan-3-OLS) chances of getting heart disease reduced.

Original title:
Flavonoid intake and risk of CVD: a systematic review and meta-analysis of prospective cohort studies by Wang X, Ouyang YY, [...], Zhao G.

Link:
http://www.ncbi.nlm.nih.gov/pubmed/23953879

Additional information about El Mondo:
A good way to get enough daily flavonoids within, through 200-300 grams of vegetables, 2-5 pieces of fruit and 1-2 glasses of alcohol per day.

Anthocyanins are formed when the anthocyanidins are linked to sugars.

Flavanonen can be found in citrus fruits. The best known are hesperitine and flavanonen are the best known flavones apigenin and Luteolin, naringenin and tangeretine.

Flavonolen are found in apples, pears, onions, tea and red wine. The most famous flavonolen are quercetin, myricetin and kaempferol.

Flavan-3-OLS are found in grapes and tea.

Product

Number of anthocyanins in mg per 100 g of product

Strawberry

15-35

Aronia berries

200-1000

Eggplant

750

Blue grape

30-750

Blueberry

25-497

Burr

83-326

Raspberry

10-60

Cherry

350-400

Radish

11-60

Red berry

80-420

Red onion

7-21

Red wine

24-35

Orange

~ 200

Cranberry  

60-200

Elderberry

450

Black currant

130-400

Product

Number of Proanthocyanidins in mg per 100 grams

Strawberry

145

(wild) Blue Berry

329

Cranberry

418

Raspberry

30

 

 

 


 

 

 

 

Product

Number of quercetin in mg per 100 g of product

 Red onions

32

Watercress

30

Carbon

23

Cranberries

15

Lingonberry

13

Black plum

12

Sweet potatoes

10

Apples

4

Broccoli

3

 Tea

 

The overview article of cohort studies indicates that eating flavonoids chances of getting heart disease lowers. That does not say that swallowing of flavonoids-supplements now justified. Swallowing of flavonoids-supplements is only justified if this protective effect is also found in the overview article of RCT studies. Until then, the food of flavonoids and not swallowing flavonoids-supplements, protection against heart disease.

Find here more studies on flavonoids.