Voedingsadvies El MondoResearch Question:
Epidemiological findings concerning the relationship between intake of heme iron and zinc and getting colon cancer deliver contradictory results. It was therefore carried out this review article.
Heme iron and zinc intake via diet increase the chances of getting colon cancer?
Study Design:
This overview article contained 8 prospective studies on heemijzerinname and 6 prospective studies on zinc intake.
There was minimal evidence of publication bias.
Results and conclusions:
The researchers found that a high heemijzerinname through feeding compared to a low intake, the chances of getting colon cancer significantly with 14% [RR = 1.14, 95% CI = 1.04-1.24] increased. Significant is, there is a link at a 95% reliability.
The researchers found that a high zinc intake via food compared to a low intake, the chances of getting colon cancer significantly with 17% [RR = 0.83, 95% CI = 0.72-0.94] reduced. Significant is, there is a link at a 95% reliability.
The researchers found in a dose-dependent analysis that each increase with 1 mg heme iron per day, the chances of getting colon cancer significantly with 11% [95% CI = 1.03-1.18] increased.
The researchers found in a dose-dependent analysis that every increase of 5 mg of zinc per day, the chances of getting colon cancer significantly with 14% [95% CI = 0.78-0.96] reduced.
The researchers concluded that heemijzerinname (1 mg or more per day) through feeding the chance of getting colon cancer increased while zinc intake (5 mg or more per day) colon cancer reduced.
Original title:
Intakes or heme iron and zinc and colorectal cancer incidence: a meta-analysis of prospective studies by Lei Qiao and Yong Feng.
Link:
http://link.springer.com/article/10.1007/s10552-013-0197-x
Additional information about El Mondo:
Heme iron is mainly in red meat and hence the recommendation by the World Cancer Research Fund: eat no more than 500 grams of red meat per week (so the chances of getting colon cancer decrease).