Flavonoïden hebben mogelijk positief effect op hart- en vaatziekten

Research Question:
Flavonoids can the chances of getting type 2 diabetes and heart disease decrease?

Study Design:
This overview article contained Rcts and cohort studies of short duration. 

Results and conclusions:
Results from both cohort studies as Rcts short-lived suggested that anthocyanidins flavan-3-OLS from berries and green tea and cocoa from the risk of getting type 2 diabetes and heart disease could be reduced.

The meta-analysis of Rcts showed that the evidence for a beneficial effect of green tea on the LDL cholesterol and a beneficial effect of flavan-3-ol-rich cocoa on the endothelial function and insulin sensitivity the strongest.

The researchers concluded that flavan-3-OLS, and anthocyanidins from berries from green tea and cocoa possible (because the Rcts were of short duration) a positive effect on both type 2 diabetes and heart disease had. More long-term Rcts are needed in order to confirm this positive effect.

Original title:
Dietary flavonoids and the development of type 2 diabetes and cardiovascular diseases: review or recent findings by van Dam R, Naidoo, N and R landberg.


Additional information about El Mondo:
To be able to find a causal link between anthocyanidins flavan-3-OLS from berries and flavan-3-OLS from green tea and cocoa and the reduced risk of getting heart disease, must be a positive effect be found in long-term Rcts (Rcts with as end points getting a heart attack, stroke or other heart or vascular disease).

Anthocyanidins and flavan-3-OLS are flavonoids. Read more about flavonoids.

Read more about RCTs, cohort studies and causal link.

Diabetes type 2 increases the chance of getting heart disease. The main cause of type 2 diabetes is overweight. Patients with type 2 diabetes have a reduced insulin sensitivity. Strength training can increase insulin sensitivity.