Koffie verlaagt de kans op het krijgen van baarmoederkanker

Research Question:
Several epidemiological studies have the relationship between coffee drinking and the risk of getting endometrial cancer (uterine cancer) examined. To provide a quantitative assessment of this connection, this meta-analysis of observational studies published until October 2011.

Drinking coffee lowers the chances of getting uterine cancer?

Study Design:
This overview article contained 10 case-control studies and cohort studies 6. This overview article contained 6628 people with uterine cancer.

Results and conclusions:
The researchers found that compared with the lowest coffee consumption, the highest coffee consumption the chance of getting uterine cancer significantly with 29% reduced [pooled RR was 0.71, 95% CI = 0.62-0.81, p = 0.13 for heterogeneity].

The pooled RR of the highest compared with the lowest coffee consumption for case-control studies was 0.69 [95% CI = 0.55-0.87], for cohort studies was 0.70 [95% CI = 0.61-0.80], for 3 Japanese studies was 0.40 [95% CI = 0.25-0.63], for 5 studies in the us/Canada was 0.69 [95% CI = 0.60-0.79], for 8 studies in Europe was 0.79 [95% CI = 0.63-0.99].

The researchers found that every increase of 1 cup of coffee a day the risk of getting uterine cancer significantly with 8% [pooled RR = 0.92, 95% CI = 0.90-0.95] did decrease. Significant is, there can be said with 95% reliability that drinking 1 cup of coffee a day really the chance of getting uterine cancer reduced by 8%.

The researchers concluded that an increased intake of coffee reduced the risk of getting uterine cancer, cohort and case-control studies consistently observed for. More large studies are needed to determine sub-groups in order to obtain benefits from drinking coffee in the relation to the risk of getting uterine cancer.

Original title:
Coffee consumption and risk of endometrial cancer: Findings from a large up-to-date meta-analysis by your Y and Giovannucci E.


Additional information about El Mondo:
Uterus cancer develops in the majority of cases in the lining (endometrium) that covered the inside of the uterus. The most common symptom of uterine cancer in women who have already had, the transition is unusual vaginal bleeding.

Uterine cancer is most common in women between 55-65 years and rarely in women under 45 years.
Uterine cancer is related to exposure to a higher content of the sex hormone oestrogen than normal.