PUFA verlaagt hart- en vaatziekten

Research Question:
A reduced intake of saturated fat is recommended to reduce coronary heart disease, but strong evidence from randomized controlled trials (Rcts) is missing. It was therefore carried out this review article.

Lowers a replacement of saturated fats by polyunsaturated fat (PUFA) chances of getting heart disease?

Study Design:
This randomized, placebo-controlled, double-blind overzichtartikel contained 8 intervention studies (Rcts) with 13614 participants, of which 1042 with heart disease. The average PUFA intake in the control group was 5 and 4% (-6.4%) and in the intervention group And was 14.9 And% (8-20.7 and%). The average follow-up time was 4.25 years.

There was no question of heterogeneity between the studies.

Results and conclusions:
The researchers found that a high intake of PUFA compared with low intake, the chance of getting heart disease significantly with 19% [95% CI = 0.70-0.95, p = 0.006] reduced. Significant is, there is a link at a 95% reliability.

The researchers found that any increase in PUFA with 5% And the chance of getting heart disease significantly with 10% [95% CI = 0.83-0.97] reduced.

The meta-regression showed that the study duration an independent determinant of the risk reduction (p = 0.017) was, with greater benefits in studies with longer follow-up duration.
The pooled RR under studies shorter than 4.25 years was 0.91 [95% CI = 0.76-1.10] and under studies longer than 4.25 year was 0.73 [95% CI = 0.61-0.87].

The researchers concluded that replacing saturated fat by PUFA chances of getting heart disease reduced.

Original title:
Effects on Coronary Heart Disease or Increasing Polyunsaturated Fat in Place of Saturated Fat: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Mozaffarian D, MICAH R and Wallace s.


Additional information about El Mondo:
Read more about saturated fat and PUFA.

14.9 And% PUFA of 2000 kcal is, that the number of grams of PUFA 14.9% contributes to 2000 kcal. 14.9% of 2000 kcal corresponds to 298 kcal. 298 kcal corresponds to 33 grams of PUFA. So a daily diet of 2000 kcal with 33 grams of PUFA is good for heart and blood vessels.

Which foods contain 33 gram PUFA, you can look up here. PUFA stands for polyunsaturated fatty acids. For example, 100 grams of soybean oil 57.9 gram PUFA.