Seleniumsupplementen verlagen mortaliteit onder patiënten met sepsis

Research Question:
Patients with sepsis (blood poisoning) benefit from swallowing selenium supplements?

Study Design:
This overview article contained 9 RCTs with 792 patients with sepsis.

Results and conclusions:
The researchers found that the risk of swallowing selenium mortality among patients with sepsis significantly with 27% [95% CI = 0.54-0.98, p = 0.03, I2 = 0%] reduced.

The researchers found that taking selenium had no significant influence on getting a nosocomial pneumonia (pneumonia after at least 48 hours at a hospital). The odds ratio was 0.83 [95% CI = 0.28-2.49, p = 0.74, I2 = 56%].

The researchers concluded that swallowing of selenium (higher than the recommended daily allowance) reduced the risk of mortality among patients with sepsis.

Original title:
The Effect or Selenium Therapy on Mortality in Patients With Sepsis Syndrome: A Systematic Review and Meta-Analysis of Randomized Controlled Trials by Jacobi J, Alhazzani W, [...], Jaeschke, RZ.


Additional information about El Mondo:
Read more about selenium.

A well-known example of a type of blood poisoning (sepsis) is the meningococcen sepsis.
People with an increased risk of sepsis are:

  • Cancer patients especially those that have been treated with chemotherapy.
  • Elderly because that often have a less effective immune system.
  • Children under 4 years.
  • Postoperative patients.
  • Patients with impaired immunity (Aids patients, patients with immunosuppressive drugs, such as Crohn's disease or rheumatism).