Vitamine D-supplementen verlagen niet borstkanker onder postmenopauzale vrouwen

Research Question:
Taking vitamin D supplements lowers the chance of getting breast cancer among postmenopausal women?

Study Design:
This overview article contained 2 RCTs with 5372 postmenopausal women.
There was no heterogeneity (p = 0.59, I2 = 0%).  

The daily dose was 800 IE (20 micrograms) vitamin D and 1000 mg of calcium for 24-62 months in one study and 1100 IE (27.5 micrograms) vitamin D and 1400 mg calcium citrate or calcium carbonate 1500 mg or in the other study.

Results and conclusions:
The researchers found that taking vitamin D supplements the chance of getting breast cancer among postmenopausal women not significantly by 11% [95% CI = 0.74-1.68] increased. Not significant is, there is no link to a 95% reliability

The researchers found that taking vitamin D supplements with the highest dosage, the chance of getting breast cancer among postmenopausal women not significantly with 42% [95% CI = 0.23-1.47] reduced. Not significant because the risk of 1 is in the 95% CI of 0.23 and 1.47. Risk of 1 means no risk.

The researchers found that taking vitamin D supplements in combination with calcium, the chance of getting breast cancer among postmenopausal women not significantly with 7% [95% CI = 0.54-1.60] reduced. Not significant is, there is no link to a 95% reliability

The researchers concluded that taking vitamin D supplements the chance of getting breast cancer among postmenopausal women not reduced. However, the available evidence is still limited and insufficient to draw firm conclusions.

Original title:
Vitamin D Supplementation and Breast Cancer Prevention: A Systematic Review and Meta-Analysis of Randomized Clinical Trials by Sperati F, Vici P, [...], Barba M.

Link:
http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone.0069269

Additional information about El Mondo:
Find here more studies on vitamin d.