Prolonged international normalized ratio values are associated with COVID-19 severity and mortality

Objectives:
D-dimer elevations, suggesting a pro-thrombotic state and coagulopathy, predict adverse outcomes in coronavirus disease 2019 (COVID-19). However, the clinical significance of other coagulation markers, particularly the international normalized ratio (INR), is not well established. Therefore, this review article has been conducted.

Dyslipidemia increases severity and mortality of COVID-19

Objectives:
The numbers of confirmed cases of coronavirus disease 2019 (COVID-19) and COVID-19 related deaths are still increasing, so it is very important to determine the risk factors of COVID-19. Dyslipidemia is a common complication in patients with COVID-19, but the association of dyslipidemia with the severity and mortality of COVID-19 is still unclear. Therefore, this review article has been conducted.

Crowded households, low income and education increase leprosy in contacts

Objectives:
What are the risk factors of leprosy in contacts?

Study design:
This review article included 23 cohort studies and 1 cross-sectional study.
Most of the studies had been conducted in Brazil and India.
The follow-up period ranged from 1 to 20 years and the publication covered the period from 1991 to 2019.
The sample ranged from 68 to 28,092 participants.
19 cohorts (79%) scored ≥ 7, indicating a low risk of bias.

Dietary calcium intake reduces colorectal adenomas

Objectives:
Does calcium reduce the risk of incidence and recurrence of colorectal adenomas and advanced adenomas?

Study design:
This review article included 37 relevant clinical trials and observational studies involving over 10,964 cases.

Results and conclusions:
The investigators found that calcium consumption significantly reduced the risk of colorectal adenomas incidence by 8% [RR = 0.92, 95% CI = 0.89 to 0.96].

Vitamin B1 supplementation reduces ICU delirium in critically ill patients

Objectives:
Do critically ill patients benefit of thiamine (vitamin B1) supplementation?

Study design:
This review article included 8 RCTs and 10 cohort studies.

Results and conclusions:
The investigators found in the analysis of RCTs, that thiamine supplementation showed a significantly 42% lower odds of developing ICU delirium [OR = 0.58, 95% CI = 0.34 to 0.98].

COVID-19 adults have a much higher level of symptomatic severity, fever and CT-positive than COVID-19 children

Objectives:
Clinical symptoms of adults and paediatric inpatients with COVID-19 disease are conflicting. Therefore, this review article has been conducted.

What is the effect of age on the severity in COVID-19 inpatients?

Study design:
This review article included 5 studies with 910 inpatients with COVID-19 disease at the baseline of the study. 773 of them were adult inpatients and 137 of them were paediatric inpatients (infants, children and adolescents).