Objectives:
Is there an association between severe COVID-19 and a change in white blood cell (WBC) count, an elevation of C-reactive protein (CRP) and fever?

Study design:
This review article included 18 studies with 3,278 patients, including 732 patients with poor outcomes.

Objectives:
What are the clinical characteristics of COVID-19 in neonates and children under one year of age?

Study design:
This review article included 18 papers covering 160 infants. One paper was from Vietnam and the other 17 were from China: 8 were cross-sectional studies, 8 were case reports, 1 was a case series and 1 was a prospective cohort study.

Results and conclusions:   
The investigators found the most common clinical symptoms were fever (54%) and cough (33%).

Objectives:
What are the overall prevalence of clinical signs, symptoms and radiological findings in children and/or adolescents with COVID-19?

Study design:
This review article included 19 eligible studies for a total of 2,855 children and/or adolescents with COVID-19. Mean age was 6.9 ± 7.0 years; 50.3% males.

Objectives:
Recent studies showed that SARS-CoV-2 RNA may be found in faecal specimens of COVID-19 patients, but the sample size is limited. Therefore, this review article has been conducted.

Objectives:
A low insulin-like growth factor 1 (IGF-1) level is known to be associated with many disorders. Several studies have shown that soy consumption may influence IGF-1, but the findings remain inconclusive. Therefore, this review article (meta-analysis) has been conducted.

Objectives:
Coronavirus disease 2019 (COVID-19) is a global pandemic impacting 213 countries/territories and more than 5,934,936 patients worldwide. Cardiac injury has been reported to occur in severe and death cases. Therefore, this review article has been conducted.

Objectives:
Glucocorticoids are widely used in the treatment of various pulmonary inflammatory diseases, but they are also often accompanied by significant adverse reactions. Published guidelines point out that low dose and short duration systemic glucocorticoid therapy may be considered for patients with rapidly progressing coronavirus disease 2019 (COVID-19) while the evidence is still limited. Therefore, this review article has been conducted.

Objectives:
Micronutrients’ deficiency is a common phenomenon among a majority of the population residing in the low- and middle-income countries (LMICs) especially among women and children. Given the widespread prevalence of micronutrients’ deficiency in LMICs, iron-fortified foods could be of potential benefits for both the mother and the development of fetus. Therefore, this review article has been conducted.

Objectives:
Do higher gestational vitamin D levels (vitamin D levels of the mother during pregnancy) decrease risk of multiple sclerosis (MS) in offspring?

Study design:
This review article included 4 case-control studies of moderate to low risk of bias.

Objectives:
Knowledge about COVID-19 in children is limited due to the paucity of reported data. The pediatric age group comprises only less than 5% of total COVID-19 worldwide. Therefore, large studies in this population are unlikely in the immediate future. Therefore, this review article has been conducted.