Reduced-dose intradermal influenza vaccination could be a reasonable alternative to standard dose intramuscular vaccination
Objectives:
To compare the immunogenicity and safety of the influenza vaccine at reduced or full intradermal doses with full intramuscular doses to inform policy design in the event of vaccine shortages.
Study design:
This review article included a total of 29 RCTs with 13,759 participants and 1 cohort study with 164,021 participants.
Approximately half of the studies (14 studies) involved only participants aged 60 years or older or reported data for participants aged 60 years or older.