Reduced-dose intradermal influenza vaccination could be a reasonable alternative to standard dose intramuscular vaccination

Objectives:
To compare the immunogenicity and safety of the influenza vaccine at reduced or full intradermal doses with full intramuscular doses to inform policy design in the event of vaccine shortages.

Study design:
This review article included a total of 29 RCTs with 13,759 participants and 1 cohort study with 164,021 participants.
Approximately half of the studies (14 studies) involved only participants aged 60 years or older or reported data for participants aged 60 years or older.

Convalescent plasma does not decrease all-cause mortality in COVID-19 patients

Objectives:
Does a treatment with convalescent plasma decrease all-cause mortality risk in COVID-19 patients?

Study design:
This review article included 4 peer-reviewed RCTs with a total of 1,060 COVID-19 patients and 6 other publicly available RCTs with 10,722 COVID-19 patients.

The mean age of patients was younger than 70 years and they were typically male (≤80%).

The certainty of the evidence was low to moderate for all-cause mortality and low for other outcomes.

Diet with <30 En% carbohydrates causally increases adiponectin concentration in adults

Objectives:
Does a low-carbohydrate diet (LCD) causally increase adiponectin concentration in adults?

Study design:
This review article included 11 RCTs with 534 participants in low-carbohydrate diet group and 513 participants in control group (group without a low-carbohydrate diet).
Proportion of carbohydrate from calorie was from 4 to 34% (4-34 En%).
Time of the follow-up varied between studies and ranged from 6 to 152 weeks.

In-hospital use of DPP4i reduces COVID-19 mortality among patients with diabetes mellitus

Objectives:
Few observational studies have shown a beneficial effect of dipeptidyl peptidase-4 inhibitors (DPP4i) in patients with coronavirus disease 2019 (COVID-19), although results are not consistent. Therefore, this review article has been conducted.

Does use of DPP4i reduce COVID-19 mortality among patients with diabetes mellitus (DM)?

Study design:
This review article included 9 observational studies of high quality pooling data retrieved from 7,008 COVID-19 patients with diabetes mellitus (DM).

Intravenous NAC administration decreases serum creatinine levels

Objectives:
N-acetylcysteine (NAC) is an antioxidant that can regenerate glutathione and is primarily used for acetaminophen overdose. NAC has been tested and used for preventing iatrogenic acute kidney injury or slowing the progression of chronic kidney disease, with mixed results. Therefore, this review article has been conducted.

Has NAC administration a positive effect on the serum creatinine level and the serum cystatin C level?

High NT-pro BNP and CK-MB levels in COVID-19 patients correlate with worse outcomes

Objectives:
Coronavirus disease 2019 (COVID-19) has been reported to cause worse outcomes in patients with underlying cardiovascular disease, especially in patients with acute cardiac injury, which is determined by elevated levels of high-sensitivity troponin. There is a paucity of data on the impact of congestive heart failure (CHF) on outcomes in COVID-19 patients. Therefore, this review article has been conducted.

What is the impact of congestive heart failure (CHF) on outcomes in COVID-19 patients?

Daily 700-1000 mg dietary calcium intake increases cardiovascular disease in healthy postmenopausal women

Objectives:
Recent systematic reviews and meta-analyses of randomized, double-blind, placebo-controlled trials (double-blind, placebo-controlled RCTs) have reported controversial findings regarding the associations between calcium supplements on the risk of cardiovascular disease (CVD). Therefore, this review article has been conducted.